Long-term persistence of gastric dysbiosis after eradication of Helicobacter pylori in patients who underwent endoscopic submucosal dissection for early gastric cancer.

Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association
Toshio WatanabeYasuhiro Fujiwara

Abstract

Gastric microbiome, other than Helicobacter pylori, plays a role in the tumorigenesis of gastric cancer (GC). Patients who undergo endoscopic submucosal dissection for early GC have a high risk of developing metachronous GC even after successful eradication of H. pylori. Thus, we investigated the microbial profiles and associated changes in such patients after the eradication of H. pylori. A total of 19 H. pylori-infected patients with early GC who were or to be treated by endoscopic resection, with paired biopsy samples at pre- and post-eradication therapy, were retrospectively enrolled. Ten H. pylori-negative patients were enrolled as controls. Biopsy samples were analyzed using 16S rRNA sequencing. H. pylori-positive patients exhibited low richness and evenness of bacteria with the deletion of several genera, including Blautia, Ralstonia, Faecalibacterium, Methylobacterium, and Megamonas. H. pylori eradication partially restored microbial diversity, as assessed during a median follow-up at 13 months after eradication therapy. However, post-eradication patients had less diversity than that in the controls and possessed a lower abundance of the five genera mentioned above. The eradication of H. pylori also altered the bacteria...Continue Reading

References

Oct 17, 1991·The New England Journal of Medicine·J ParsonnetR K Sibley
Oct 17, 1991·The New England Journal of Medicine·A NomuraM J Blaser
Jan 13, 2006·Proceedings of the National Academy of Sciences of the United States of America·Elisabeth M BikDavid A Relman
Jul 31, 2008·PloS One·Anders F AnderssonLars Engstrand
Nov 26, 2010·Journal of Gastroenterology·Susumu TakeKazuhide Yamamoto
Jan 25, 2012·Journal of the National Cancer Institute·Jun-Ling MaMitchell H Gail
Jun 4, 2014·International Journal of Cancer. Journal International Du Cancer·Martyn PlummerCatherine de Martel
May 16, 2015·Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation·Robert R JenqMarcel R M van den Brink
Aug 25, 2015·Applied and Environmental Microbiology·Mireia Lopez-SilesL Jesús Garcia-Gil
Oct 1, 2015·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Genki MoriIchiro Oda
Jul 22, 2017·Frontiers in Cellular and Infection Microbiology·Guoqin YuAlisa M Goldstein
Aug 3, 2017·Gut·Olabisi Oluwabukola CokerJun Yu
Feb 11, 2018·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Masahiro MaedaToshikazu Ushijima
Mar 22, 2018·The New England Journal of Medicine·Il Ju ChoiByung-Ho Nam
May 13, 2020·Helicobacter·Muhammad MiftahussururYoshio Yamaoka

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Citations

May 20, 2021·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Toshio WatanabeYasuhiro Fujiwara
Jun 3, 2021·International Journal of Molecular Sciences·Paulius JonaitisJuozas Kupcinskas
Jun 12, 2021·Current Opinion in Physiology·Carolina SerranoDiane Bimczok
Jul 3, 2021·Journal of Clinical Medicine·Toshihiro NishizawaHidekazu Suzuki
Nov 7, 2021·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Karolina Kaźmierczak-SiedleckaKarol Połom

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