Long-term persistence of tissue-engineered adipose flaps in a murine model to 1 year: an update

Plastic and Reconstructive Surgery
Michael FindlayW A Morrison

Abstract

Tissue engineering of patient-specific adipose tissue has the potential to revolutionize reconstructive surgery. Numerous models have been described for the production of adipose tissue with success in the short term, but little has been reported on the stability of this tissue-engineered fat beyond 4 months. A murine model of de novo adipogenesis producing a potentially transplantable adipose tissue flap within 4 to 6 weeks was developed in the authors' laboratory. In this study, the authors assess the ability of three-chamber (44-microl volume) configurations shown to be adipogenic in previous short-term studies (autograft, n = 8; open, n = 6; fat flap, n = 11) to maintain their tissue volume for up to 12 months in vivo, to determine the most adipogenic configuration in the long term. Those chambers having the most contact with existing vascularized adipose tissue (open and fat flap groups) showed increased mean adipose tissue percentage (77 +/- 5.6 percent and 81 +/- 6.9 percent, respectively; p < 0.0007) and volume (12 +/- 6.8 microl and 30 +/- 14 microl, respectively; p < 0.025) when compared with short-term controls and greater adipose tissue volume than the autograft (sealed) chamber group (4.9 +/- 5.8 microl; p = 0.0001...Continue Reading

References

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Citations

Jun 18, 2011·Expert Opinion on Drug Delivery·Katharina Ladewig
Nov 3, 2010·ANZ Journal of Surgery·Richard TeeRodney J Dilley
Oct 31, 2013·Journal of Tissue Engineering and Regenerative Medicine·Katharina WittmannTorsten Blunk
Apr 17, 2010·Advanced Drug Delivery Reviews·Petra Bauer-KreiselTorsten Blunk
Aug 26, 2017·Plastic and Reconstructive Surgery·Jingjing MaJianhua Gao
Mar 18, 2016·Plastic and Reconstructive Surgery·Jinlin WanFeng Lu
Apr 26, 2014·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Masaki YazawaKazuo Kishi
Jul 14, 2017·Scientific Reports·Myung Chul LeeYong Oock Kim

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