Long-term persistence of TNF-inhibitor treatment in patients with psoriatic arthritis. Data from the British Society for Rheumatology Biologics Register

RMD Open
Karen Minde FagerliKimme L Hyrich

Abstract

Long-term effectiveness of tumour necrosis factor alpha inhibitors (TNFi) has mainly been explored in patients with rheumatoid arthritis (RA) and the data available on patients with psoriatic arthritis (PsA) includes limited follow-up. Investigate long-term effectiveness of first TNFi in a PsA population by describing treatment persistence, identify factors associated with 5-year persistence and further investigate comparative long-term effectiveness of subsequent TNFi treatments through persistence to treatment. Patients with a rheumatologist diagnosis of PsA receiving their first TNFi registered in the British Society for Rheumatology Biologics Register (BSRBR) (2002-2006) were included. Treatment at different time points was described and factors associated with 5-year treatment persistence were identified by logistic regression. Kaplan-Meier analysis was used to assess factors associated with persistence to first TNFi and subsequent TNFi treatments. At 5 years, 46.7% of patients were still on their initial TNFi treatment. Better 5 -year persistence was associated with male gender, use of etanercept or adalimumab rather than infliximab and absence of baseline comorbidity. Five-year persistence estimates (95% CI) of first, se...Continue Reading

Citations

Jun 14, 2019·Expert Review of Clinical Immunology·Michael Ruberson Ribeiro da SilvaFrancisco de Assis Acurcio
Mar 10, 2019·Rheumatology·Lianne Kearsley-FleetUNKNOWN Biologics for Children with Rheumatic Diseases (BCRD) Study and the British Society for Paediatric and Adolescent Rheumatolo
Sep 16, 2019·The European Journal of Health Economics : HEPAC : Health Economics in Prevention and Care·Axel SvedbomSumesh Kachroo
Apr 21, 2020·Journal of Managed Care & Specialty Pharmacy·George BungeyJohn Woolcott
Jan 23, 2019·European Journal of Clinical Pharmacology·Karel Kostev, Louis Jacob
Nov 27, 2018·Rheumatology International·Louis JacobKarel Kostev
Mar 2, 2019·Future Science OA·Michael Ruberson Ribeiro da SilvaFrancisco de Assis Acurcio
Jan 31, 2021·Arthritis Research & Therapy·Amir HaddadDevy Zisman
Jan 8, 2021·Rheumatology Advances in Practice·Kirk GealeElke Theander
May 19, 2021·Expert Review of Clinical Immunology·Jonathan P E White, Laura C Coates

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