Long-term persistence of translocations in stable lymphocytes from victims of a radiological accident

International Journal of Radiation Biology
C Lindholm, A Edwards

Abstract

To investigate whether translocations in 'stable' lymphocytes, i.e. those not containing unstable aberrations in any chromosome including counterstained ones, would have a longer persistence with time compared with those measured in all cells. The time-course of chromosomal aberrations in the three most highly exposed radiation victims of an Estonian accident in November 1994 was followed for 7 post-accident years encompassing 15 samples. Chromosome painting was performed using probes for chromosomes 1, 2 and 4 with a pan-centromeric probe, and chromosomal aberrations involving the painted chromosomes were scored using a developed version of the Protocol for Aberration Identification and Nomenclature Terminology (PAINT) nomenclature. Metaphases containing aberrations were captured with an image analyser and stored on a computer. An earlier analysis of aberrations in the painted portion of the genome was performed in all cells, irrespective of the possible aberrations in the unpainted part of the genome. The present analysis has taken into account the 'stable/unstable' nature of the complete cell. Evaluation was performed on images, counting all chromosomes and checking the counterstained chromosomes for unstable aberrations, i....Continue Reading

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Citations

Dec 25, 2010·Radiation Protection Dosimetry·E A AinsburyK Rothkamm
Aug 22, 2007·The British Journal of Radiology·A A EdwardsD C Lloyd
Aug 3, 2006·International Journal of Radiation Biology·E GregoireL Roy
Mar 10, 2010·Environmental and Molecular Mutagenesis·James D Tucker
Dec 21, 2004·Applied Radiation and Isotopes : Including Data, Instrumentation and Methods for Use in Agriculture, Industry and Medicine·Dieter F Regulla
Oct 29, 2005·International Journal of Radiation Oncology, Biology, Physics·Irene MüllerHorst Zitzelsberger
Jun 23, 2005·Environmental and Molecular Mutagenesis·Anne KiuruSisko Salomaa
Jan 25, 2018·International Journal of Radiation Biology·Eric GrégoireJoan Francesc Barquinero
Jun 2, 2005·Radiation Protection Dosimetry·A A EdwardsP Voisin
Feb 9, 2021·Mutation Research. Genetic Toxicology and Environmental Mutagenesis·Adayabalam S Balajee, Valeria Hadjidekova

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