PMID: 8968018Dec 18, 1996Paper

Long-term pharmacotherapy in the management of obesity. National Task Force on the Prevention and Treatment of Obesity

JAMA : the Journal of the American Medical Association

Abstract

To examine the rationale for long-term use of medications in the management of obesity, to provide an overview of published scientific information on their safety and efficacy, and to provide guidance to patients and practitioners regarding risks and benefits of treatment. Original reports and reviews obtained through electronic database searches on anorexiant drugs supplemented by a manual search of bibliographies. English-language articles that discussed the role of medications in the treatment of human obesity, and studies that evaluated their safety and efficacy for a minimum of 24 weeks. Studies were reviewed by experts in the fields of nutrition, obesity, and eating disorders to evaluate study design and the validity of authors' conclusions. The long-term use of medications in the management of obesity is consistent with the current consensus that obesity responds poorly to short-term interventions. Net weight loss attributable to medication is modest, ranging from 2 to 10 kg, but patients taking active drug are more likely to lose 10% or more of initial body weight. Weight loss tends to reach a plateau by 6 months. Weight remains below baseline throughout treatment, although some studies show partial weight regain despit...Continue Reading

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