PMID: 9004050Feb 1, 1997Paper

Long-term pharmacotherapy of obsessive-compulsive disorder: a double-blind controlled study

Journal of Clinical Psychopharmacology
E MundoE Smeraldi

Abstract

The aim of this study was to investigate whether obsessive-compulsive patients previously treated successfully with clomipramine or fluvoxamine could tolerate reduction of the daily dosage without worsening of the clinical condition. Thirty informed obsessive-compulsive patients, given a diagnosis according to DSM-III-R criteria, were recruited consecutively into the study. Patients were blindly assigned to one of the groups of treatment with different rates of reduction of the previously effective daily drug dosage: group 1 (control group, no reduction), group 2 (reduction of 33-40%), and group 3 (reduction of 60-66%). The entire study lasted 102 days. From baseline to the end of the study, the clinical condition was evaluated by the administration of standardized tests (Yale-Brown Obsessive-Compulsive Scale, Hamilton Rating Scale for Depression, Clinical Global Impression [CGI] scale), and blood samples were collected for plasma drug level determinations. The criterion for discontinuation of the study was the worsening of obsessive-compulsive symptoms, arbitrarily defined by an increase of > 5% from the baseline total Yale-Brown Obsessive-Compulsive Scale score, as measured in two successive assessments, and a worsening of gl...Continue Reading

References

Apr 1, 1991·The Journal of Clinical Psychiatry·S Lee
Jan 1, 1989·Archives of General Psychiatry·W K GoodmanD S Charney
Jul 1, 1989·The American Journal of Psychiatry·M A JenikeA Holland
Sep 1, 1987·Journal of Affective Disorders·J Zohar, T R Insel
Aug 1, 1987·The American Journal of Psychiatry·L H PriceG R Heninger
Apr 1, 1986·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·J Ananth
Jan 1, 1985·Progress in Neuro-psychopharmacology & Biological Psychiatry·R Fontaine, G Chouinard
Aug 1, 1985·Journal of Clinical Psychopharmacology·S M TurnerJ Himmelhoch
Oct 1, 1985·Archives of General Psychiatry·M F FlamentM Linnoila
Jan 1, 1980·Progress in Neuro-psychopharmacology·L E EvansT Van Hees
Nov 1, 1980·Archives of General Psychiatry·P ThorénL Träskman
Aug 1, 1995·Journal of Clinical Psychopharmacology·E MundoL Bellodi
Jul 1, 1994·Archives of General Psychiatry·G D TollefsonL A Genduso
Mar 1, 1994·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·E SeifritzP Baumann
Feb 1, 1960·Journal of Neurology, Neurosurgery, and Psychiatry·M HAMILTON

❮ Previous
Next ❯

Citations

Mar 14, 2002·Depression and Anxiety·Christine LochnerDan J Stein
Apr 25, 2012·Current Psychiatry Reports·Dan J SteinH Blair Simpson
Oct 5, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Rosa Maria MorescoFerruccio Fazio
Jan 16, 2004·The New England Journal of Medicine·Michael A Jenike
Nov 13, 2002·Journal of Child and Adolescent Psychopharmacology·Daniel S Pine
Jun 27, 2009·Neuropsychiatric Disease and Treatment·Lídia OrdacgiLeonardo F Fontenelle
Mar 1, 2006·Progress in Neuro-psychopharmacology & Biological Psychiatry·Stefano Pallanti, Leonardo Quercioli
Mar 8, 2005·Pediatric Clinics of North America·Swati Bhave, Jitendra Nagpal
Nov 6, 2012·The Australian and New Zealand Journal of Psychiatry·Naomi A FinebergIlenia Pampaloni
Jan 1, 2014·Expert Review of Neurotherapeutics·Shyam Sundar Arumugham, Y C Janardhan Reddy
May 15, 2002·Journal of Clinical Psychopharmacology·Emanuela MundoSilvio R Bareggi
Apr 22, 1999·Journal of Clinical Psychopharmacology·C L AlfaroL Ereshefsky
Mar 17, 1999·Canadian Journal of Psychiatry. Revue Canadienne De Psychiatrie·K O'ConnorM Brault
May 15, 2002·Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences·R PirolaS R Bareggi

❮ Previous
Next ❯

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.