Long-term plasma levels of leptin and adiponectin in Rett syndrome

Clinical Endocrinology
P BlardiJ Hayek

Abstract

Rett syndrome is a progressive neurological disorder affecting almost exclusively females after age 6 months and characterised by acquired microcephaly, psychomotor retardation, growth failure, purposeless hand movements, autistic-like behaviour and wide-based and stiff legged gait. Leptin and adiponectin, peptides secreted by adipose tissue, are involved in the regulation of body weight and energy expenditure. We investigated in patients with Rett syndrome the variations of plasma leptin and adiponectin and their relation over a 2-year period. Sixteen female patients, mean age at the basal time 9.4 +/- 4.3 years, with classical Rett syndrome were enrolled. Controls were 16 healthy female subjects, mean age at the basal time 9.9 +/- 3.4 years. Blood samples were withdrawn in the morning at the baseline, 12 months after and 24 months after; plasma leptin and adiponectin concentrations were detected by ELISA. In patients, leptin concentrations significantly increased, while adiponectin concentrations significantly decreased. Both leptin and adiponectin values were significantly higher than those found in controls at each time. Leptin significantly correlated with adiponectin in patients, while there was not a significant correlat...Continue Reading

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Citations

Jul 4, 2012·BMC Pediatrics·Asimenia AngelidouTheoharis C Theoharides
Dec 29, 2012·Brain & Development·Olivia KnightHelen Leonard
Jun 21, 2011·Brain & Development·Patrizia BlardiAlberto Auteri
May 19, 2010·Neuroscience Letters·Patrizia BlardiJoseph Hayek
Jul 28, 2015·The Journal of Clinical Investigation·Navasona KrishnanNicholas K Tonks
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Aug 16, 2019·Disease Models & Mechanisms·Yijie Geng, Randall T Peterson
Dec 15, 2019·Brain Sciences·Margherita ProsperiElisa Santocchi
Jul 26, 2018·Journal of Autism and Developmental Disorders·Ramkripa RaghavanXiaobin Wang
Jul 10, 2019·International Journal of Molecular Sciences·Marco SegattoValentina Pallottini
Aug 6, 2019·Frontiers in Integrative Neuroscience·Victor FaundezDaniel Tarquinio

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