Long-term polarization of microglia upon α-synuclein overexpression in nonhuman primates

Neuroscience
P BarkholtMarina Romero-Ramos

Abstract

We have previously shown that persistent α-synuclein overexpression in ventral midbrain of marmoset leads to a distinctive neurodegenerative process and motor defects. The neurodegeneration was confined to caudate putamen dopaminergic fibers in animals overexpressing wild-type (wt) α-synuclein. However, A53T α-synuclein overexpression induced neurodegeneration that resulted in nigral dopaminergic cell death. Here, we analyze the microglia population in the midbrain of these animals by stereological quantification of Iba1+ cells. Our data here show that monkeys overexpressing A53T α-synuclein showed a long-term increase in microglia presenting macrophagic morphology. However, wt α-synuclein overexpression, despite the absence of dopaminergic cell death, resulted in a permanent robust increase of the microglia population characterized by a range of distinct morphological types that persisted after 1 year. These results confirm that the microglial response differs depending on the type of α-synuclein (wt/A53T) and/or whether α-synuclein expression results in cell death or not, suggesting that microglia may play different roles during disease progression. Furthermore, the microglial response is modulated by events related to α-synu...Continue Reading

References

Sep 1, 1987·Journal of Microscopy·H J Gundersen, E B Jensen
Aug 1, 1996·Trends in Neurosciences·G W Kreutzberg
Oct 16, 2002·Glia·Yoshinori Imai, Shinichi Kohsaka
Nov 5, 2002·Methods : a Companion to Methods in Enzymology·Sergei ZolotukhinRichard O Snyder
Nov 1, 2003·Science·A B SingletonK Gwinn-Hardy
Feb 6, 2004·Journal of Neurochemistry·Keiko OhsawaShinichi Kohsaka
Sep 29, 2004·Lancet·Marie-Christine Chartier-HarlinAlain Destée
May 17, 2005·Nature Neuroscience·Dimitrios DavalosWen-Biao Gan
Jun 15, 2005·Journal of Neuroscience Research·Seung U Kim, Jean de Vellis
Oct 13, 2005·Brain : a Journal of Neurology·Carolyn F OrrGlenda M Halliday
Feb 17, 2007·Brain : a Journal of Neurology·Andisheh EslamboliDeniz Kirik
Aug 22, 2008·Neurobiology of Aging·Nicholas M KanaanTimothy J Collier
Jan 24, 2009·Apoptosis : an International Journal on Programmed Cell Death·Oren A LevyLloyd A Greene
Apr 3, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Hiroaki WakeJunichi Nabekura
Aug 15, 2009·Journal of Neuropathology and Experimental Neurology·Marianne Vázquez-ClaverieMaría-Rosario Luquin
Jan 25, 2011·Neuroscience Research·Lydia Alvarez-ErvitiMatthew J A Wood
Apr 30, 2011·Physiological Reviews·Helmut KettenmannAlexei Verkhratsky

❮ Previous
Next ❯

Citations

Feb 5, 2013·Journal of Neuroimmune Pharmacology : the Official Journal of the Society on NeuroImmune Pharmacology·Fabio Blandini
May 30, 2013·Molecular Therapy. Nucleic Acids·Hironori OkadaTakashi Okada
Jul 3, 2015·Expert Opinion on Therapeutic Targets·Nada B LawandBared Safieh-Garabedian
Apr 7, 2015·European Journal of Pharmacology·Romina Aron BadinPhilippe Hantraye
Dec 3, 2014·Neuroscience·M S Moehle, A B West
Apr 25, 2016·Progress in Neurobiology·Valerie JoersAnna R Carta
Mar 3, 2018·Frontiers in Molecular Neuroscience·Matthew J BenskeyFredric P Manfredsson
Jul 17, 2018·Synapse·Thea Pinholt LillethorupAnne M Landau
Nov 27, 2018·The European Journal of Neuroscience·Malú G Tansey, Marina Romero-Ramos
May 12, 2018·Acta Neuropathologica Communications·Martin Timo HenrichWolfgang Hermann Oertel
Mar 19, 2016·Oncotarget·Sandeep Vasant More, Dong-Kug Choi
Mar 23, 2017·Reviews in the Neurosciences·Hossein Sanjari MoghaddamNima Rezaei
Jul 11, 2018·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Ana I Rodriguez-PerezJose L Labandeira-Garcia
Apr 4, 2019·Frontiers in Neurology·Marie Therese Fuzzati-ArmenteroFabio Blandini
Oct 6, 2020·Frontiers in Cell and Developmental Biology·Maria FoukaMaria Xilouri
Jun 24, 2017·Frontiers in Aging Neuroscience·Sudhakar R Subramaniam, Howard J Federoff
Aug 22, 2018·Frontiers in Cellular Neuroscience·Sara A Ferreira, Marina Romero-Ramos
Jul 3, 2019·Frontiers in Cellular Neuroscience·Violetta Refolo, Nadia Stefanova
Feb 9, 2021·Acta Neuropathologica·Ashley S HarmsMarina Romero-Ramos
Jun 3, 2021·International Journal of Molecular Sciences·Panagiota Mavroeidi, Maria Xilouri
Nov 2, 2021·Journal of Neurology·Peng-Fei Zhang, Fan Gao

❮ Previous
Next ❯

Related Concepts

Related Feeds

Alpha-Synuclein Aggregation (MDS)

Alpha-synucleins are small proteins that are believed to restrict the mobility of synpatic vesicles and inhibit neurotransmitter release. Aggregation of these proteins have been linked to several types of neurodegenerative diseases including dementia with Lewy bodies and Parkinson's disease. Here is the latest research on α-synuclein aggregation.

Cell-Type-Specific Viral Vectors (ASM)

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Amygdala and Midbrain Dopamine

The midbrain dopamine system is widely studied for its involvement in emotional and motivational behavior. Some of these neurons receive information from the amygdala and project throughout the cortex. When the circuit and transmission of dopamine is disrupted symptoms may present. Here is the latest research on the amygdala and midbrain dopamine.

Cell-Type-Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Cell-Type Specific Viral Vectors

Viral vectors are used in biological research and therapy to deliver genetic material into cells. However, the efficiency of viral vectors varies depending on the cell type. Here is the latest research on cell-type-specific viral vectors.

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.