Long-term population spike-timing-dependent plasticity promotes synaptic tagging but not cross-tagging in rat hippocampal area CA1

Proceedings of the National Academy of Sciences of the United States of America
Karen Ka Lam PangSreedharan Sajikumar

Abstract

In spike-timing-dependent plasticity (STDP), the direction and degree of synaptic modification are determined by the coherence of pre- and postsynaptic activities within a neuron. However, in the adult rat hippocampus, it remains unclear whether STDP-like mechanisms in a neuronal population induce synaptic potentiation of a long duration. Thus, we asked whether the magnitude and maintenance of synaptic plasticity in a population of CA1 neurons differ as a function of the temporal order and interval between pre- and postsynaptic activities. Modulation of the relative timing of Schaffer collateral fibers (presynaptic component) and CA1 axons (postsynaptic component) stimulations resulted in an asymmetric population STDP (pSTDP). The resulting potentiation in response to 20 pairings at 1 Hz was largest in magnitude and most persistent (4 h) when presynaptic activity coincided with or preceded postsynaptic activity. Interestingly, when postsynaptic activation preceded presynaptic stimulation by 20 ms, an immediate increase in field excitatory postsynaptic potentials was observed, but it eventually transformed into a synaptic depression. Furthermore, pSTDP engaged in selective forms of late-associative activity: It facilitated the m...Continue Reading

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Citations

Jan 17, 2020·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuxin ZhouXuanmao Chen
Mar 16, 2021·Frontiers in Molecular Neuroscience·Benjamin T Goult
Apr 4, 2021·Brain Sciences·Yosef Avchalumov, Chitra D Mandyam
Jun 11, 2021·The FEBS Journal·Mohammad Zaki Bin IbrahimSreedharan Sajikumar

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