Long-term positive severe acute respiratory syndrome coronavirus 2 ribonucleic acid and therapeutic effect of antivirals in patients with coronavirus disease: Case reports

Revista Da Sociedade Brasileira De Medicina Tropical
Bo WeiJunxue Wang

Abstract

Coronavirus disease (COVID-19), caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has been declared a pandemic. We herein report four COVID-19 cases with long-term positive viral ribonucleic acid (RNA) for about 61 days. Despite treatment with recombinant human interferon, convalescent plasma from COVID-19 patients, arbidol, etc., nucleic acid results were still positive for SARS-CoV-2. After treatment with ritonavir-boosted danoprevir (DNVr, 100/100 mg, once daily), all four patients showed two to three consecutive negative SARS-CoV-2 RNA and were thus discharged from hospital. Therefore, DNVr may be a potentially effective antiviral for COVID-19 patients with long-term positive SARS-CoV-2 RNA.

References

Jan 26, 2020·Journal of Medical Virology·Geng LiJianguo Wu
Apr 3, 2020·Nature·Roman WölfelClemens Wendtner
Apr 14, 2020·JAMA : the Journal of the American Medical Association·James M SandersJames B Cutrell
May 1, 2020·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Susanna FelsensteinChristian M Hedrich
Aug 18, 2020·Combinatorial Chemistry & High Throughput Screening·Sekhar Talluri

❮ Previous
Next ❯

Citations

Apr 8, 2021·JMIR Public Health and Surveillance·Henry T PengAndrew Beckett

❮ Previous
Next ❯

Methods Mentioned

BETA
dissection

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.