Long term potentiation affects intracellular metalloproteinases activity in the mossy fiber-CA3 pathway.

Molecular and Cellular Neurosciences
Grzegorz WieraJerzy W Mozrzymas

Abstract

Matrix Metalloproteinases (MMPs) are a family of endopeptidases known to process extracellular proteins. In the last decade, studies carried out mainly on the Schaffer collateral-CA1 hippocampal projection have provided solid evidence that MMPs regulate synaptic plasticity and learning. Recently, our group has shown that MMP blockade disrupts LTP maintenance also in the mossy fiber-CA3 (mf-CA3) projection (Wojtowicz and Mozrzymas, 2010), where LTP mechanisms are profoundly different (NMDAR-independent and presynaptic expression site). However, how plasticity of this pathway correlates with activity and expression of MMPs remains unknown. Interestingly, several potential MMP substrates (especially of gelatinases) are localized intracellularly but little is known about MMP activity in this compartment. In the present study we have asked whether LTP is associated with the expression and activity of gelatinases in apparent intra- and extracellular compartments along mf-CA3 projection. In situ zymography showed that LTP induction was associated with increased gelatinases activity in the cytoplasm of the hilar and CA3 neurons. Using gelatin zymography, immunohistochemistry and immunofluorescent staining we found that this effect was ...Continue Reading

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Citations

Jan 2, 2014·Journal of Cardiovascular Translational Research·Reid G HendryDavid J Marchant
Nov 20, 2015·Frontiers in Cellular Neuroscience·Grzegorz Wiera, Jerzy W Mozrzymas
Sep 1, 2015·Frontiers in Cellular Neuroscience·Tomasz WójtowiczJerzy W Mozrzymas
Jun 25, 2014·Brain Structure & Function·Jeroen AertsLutgarde Arckens
Aug 19, 2015·Frontiers in Cellular Neuroscience·Sarah M ReinhardIryna M Ethell
Jul 30, 2014·Frontiers in Neuroanatomy·Michal StawarskiJakub Wlodarczyk
Nov 1, 2016·Journal of Neurochemistry·Behnam VafadariLeszek Kaczmarek
Apr 15, 2018·The Biochemical Journal·Tyler DuellmanJay Yang
Jan 21, 2017·Mediators of Inflammation·Elżbieta Bronisz, Iwona Kurkowska-Jastrzębska
May 28, 2019·Frontiers in Molecular Neuroscience·Seham Alaiyed, Katherine Conant

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