Long-term potentiation and dual-component quantal signaling in the dentate gyrus

Proceedings of the National Academy of Sciences of the United States of America
M Y MinD M Kullmann

Abstract

Long-term potentiation (LTP) of excitatory transmission is an important candidate cellular mechanism for the storage of memories in the mammalian brain. The subcellular phenomena that underlie the persistent increase in synaptic strength, however, are incompletely understood. A potentially powerful method to detect a presynaptic increase in glutamate release is to examine the effect of LTP induction on the rate at which the use-dependent blocker MK-801 attenuates successive N-methyl-D-aspartic acid (NMDA) receptor-mediated synaptic signals. This method, however, has given apparently contradictory results when applied in hippocampal CA1. The inconsistency could be explained if NMDA receptors were opened by glutamate not only released from local presynaptic terminals, but also diffusing from synapses on neighboring cells where LTP was not induced. Here we examine the effect of pairing-induced LTP on the MK-801 blocking rate in two afferent inputs to dentate granule cells. LTP in the medial perforant path is associated with a significant increase in the MK-801 blocking rate, implying a presynaptic increase in glutamate release probability. An enhanced MK-801 blocking rate is not seen, however, in the lateral perforant path. This r...Continue Reading

References

Jan 1, 1981·Experimental Brain Research·A M TielenW J Mollevanger
Dec 1, 1993·Trends in Neurosciences·R C Malenka, R A Nicoll
Oct 29, 1993·Science·C RosenmundG L Westbrook
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Feb 1, 1997·Neuron·J T IsaacR C Malenka
Feb 17, 1998·Trends in Neurosciences·D M Kullmann, F Asztely

❮ Previous
Next ❯

Citations

Jul 10, 2004·Journal of Physiology, Paris·Jean Christophe Poncer
Jun 14, 2000·Current Opinion in Neurobiology·R MalinowY Hayashi
May 10, 2003·Neurobiology of Learning and Memory·Yolanda RoblesSandra Peña de Ortiz
Sep 13, 2011·Nature Neuroscience·Maria Amalia Di CastroAndrea Volterra
Jun 26, 1999·Acta Physiologica Scandinavica·D M Kullmann
Mar 11, 2000·The European Journal of Neuroscience·F AsztelyO Lindvall
Apr 23, 1999·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·D M KullmannD A Rusakov
May 11, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Andras SzaboKarri P Lamsa
Sep 14, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Robert F HuntScott C Baraban
Jan 30, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Iris OrenKarri P Lamsa
Jun 12, 2009·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Licurgo de AlmeidaJohn E Lisman
May 16, 1998·Proceedings of the National Academy of Sciences of the United States of America·L E Dobrunz
Feb 3, 1999·Proceedings of the National Academy of Sciences of the United States of America·K E Vogt, R A Nicoll
Jan 5, 2005·Proceedings of the National Academy of Sciences of the United States of America·Eva SykováJan Bures
Oct 10, 2012·Proceedings of the National Academy of Sciences of the United States of America·Rosemary C BagotMichael J Meaney
Feb 22, 2012·The Journal of Physiology·Dimitri M Kullmann
May 4, 2011·The European Journal of Neuroscience·Fumiko Arima-YoshidaToshiya Manabe
Aug 16, 2005·Progress in Neurobiology·Clive R Bramham, Elhoucine Messaoudi
Sep 22, 1998·Current Biology : CB·E P Huang
Dec 29, 2011·Neuropharmacology·Judith RohdeRüdiger Köhling
Nov 12, 2005·Journal of Neurophysiology·Annalisa ScimemiMatthew C Walker
Jun 4, 2019·Proceedings of the National Academy of Sciences of the United States of America·Iaroslav SavtchoukAndrea Volterra
Sep 16, 2016·Frontiers in Cell and Developmental Biology·Dongwon LeeKeiko Tanaka-Yamamoto
Sep 3, 2020·Nature Communications·Rafael Falcón-MoyaAntonio Rodríguez-Moreno
Jul 30, 2002·Journal of Biomedical Science·Ming-Yuan MinHsui-Wen Yang
Apr 4, 2021·Brain Sciences·Yosef Avchalumov, Chitra D Mandyam

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.