Long-term potentiation and functional synapse induction in developing hippocampus

Nature
G M DurandA Konnerth

Abstract

Long-term potentiation (LTP) is a cellular mechanism that potentially underlies learning and memory. To test the hypothesis that LTP is involved in activity-dependent synapse formation, we combined whole-cell recordings and confocal microscopy to investigate hippocampal glutamatergic synapses at their earliest stages of development. Here we report that, during the first postnatal week, the hippocampal glutamatergic network becomes gradually functional owing to the transformation of precursor, pure NMDA (N-methyl-D-aspartate)-receptor-based synaptic contacts into conducting AMPA (alpha-amino-3-hydroxy-5-methylisoxazole-4-proprionate)/NMDA-re cep tor-type synapses. This functional synapse induction is caused by an associative form of LTP, so it is input-specific and easily triggered experimentally by pairing presynaptic stimulation with postsynaptic depolarization. Our results challenge previous views that LTP occurs in the hippocampus only at later stages of development and that its induction requires dendritic spines. They also provide direct evidence that LTP is important for the activity-dependent formation of conducting glutamatergic synapses in the developing mammalian brain.

References

Aug 1, 1990·Trends in Neurosciences·A Konnerth
Nov 1, 1990·Pflügers Archiv : European journal of physiology·A KonnerthA Lev-Tov
Apr 1, 1988·Trends in Neurosciences·B Gustafsson, H Wigström
Sep 1, 1989·Pflügers Archiv : European journal of physiology·F A EdwardsT Takahashi
Jan 1, 1984·The Journal of Physiology·K M Harris, T J Teyler
Oct 24, 1995·Proceedings of the National Academy of Sciences of the United States of America·J EilersA Konnerth
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Nov 1, 1949·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·C O HEBB, H KONZETT

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Citations

Sep 30, 1999·Journal of Neurobiology·M F Bear, C D Rittenhouse
Jan 5, 2002·Mental Retardation and Developmental Disabilities Research Reviews·Y H RaolA R Brooks-Kayal
Sep 25, 2009·Experimental Brain Research·Kurt GottmannVolkmar Lessmann
Nov 3, 2010·Molecular Neurobiology·Enrico CherubiniLaura Lagostena
Mar 17, 2004·Biochemical and Biophysical Research Communications·Hang LinDezhi Liao
Mar 24, 2004·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Kazuyuki KiyosueTakahisa Taguchi
Mar 24, 2004·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Eric A BushongMark H Ellisman
Dec 12, 2003·Journal of Neuroscience Methods·Alexander E DityatevLeon L Voronin
Jan 7, 2004·Journal of Physiology, Paris·Xavier Leinekugel
Jul 10, 2004·Journal of Physiology, Paris·Jean Christophe Poncer
May 17, 2005·Molecular and Cellular Neurosciences·Ronald S PetraliaRobert J Wenthold
Apr 29, 2005·Brain Research. Molecular Brain Research·Paul T KellyJ Wang
May 5, 2004·Neurobiology of Aging·Y GeinismanM Gallagher
Aug 9, 2003·Neuropharmacology·Leon L Voronin, Enrico Cherubini
Aug 9, 2003·Neuropharmacology·John T R Isaac
Apr 16, 1998·Journal of Neuroscience Methods·A V AstrelinL L Voronin
Dec 13, 2000·Brain Research. Developmental Brain Research·G L YeB L Trommer
Dec 18, 2001·Brain Research. Developmental Brain Research·F ShuK Sato
May 24, 2003·Brain Research. Developmental Brain Research·Myeong Ok KimJean-Pierre Hornung
Jul 18, 1997·Brain Research. Developmental Brain Research·P Kortekaas, W J Wadman
Jun 24, 1998·Brain Research. Developmental Brain Research·S StandleyM Baudry
May 18, 2001·Trends in Neurosciences·Y Ben-Ari
Oct 24, 2002·Trends in Neurosciences·Insuk Song, Richard L Huganir
Jul 10, 2003·Trends in Neurosciences·Haruo KasaiHiroyuki Nakahara
Nov 19, 1997·Trends in Neurosciences·Y Ben-AriJ L Gaiarsa
Feb 17, 1998·Trends in Neurosciences·D M Kullmann, F Asztely
Mar 12, 1998·Brain Research. Molecular Brain Research·M Ishihara-Sugano, H Nakae
Nov 19, 1997·Neurochemistry International·M Knipper, R J Rylett
May 23, 2001·Progress in Neurobiology·N C Danbolt

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