PMID: 9159501Apr 25, 1997Paper

Long-term potentiation and long-term depression are induced through pharmacologically distinct NMDA receptors

Neuroscience Letters
S Hrabetova, T C Sacktor

Abstract

N-Methyl-D-aspartate (NMDA) receptor activation initiates both homosynaptic long-term depression (LTD) and long-term potentiation (LTP) in the CA1 region of the hippocampus. The mechanism by which two opposing forms of synaptic plasticity can be initiated through the activation of a single receptor is not known. We examined the effects of two competitive antagonists on the induction of LTP and LTD, D-2-amino-5-phosphonovaleric acid (D-AP5), a broad spectrum inhibitor of the NMDA receptor, and 3-((RS)-2-carboxypiperazin-4-yl)propyl-1-phosphonic acid (CPP), an antagonist that binds with high affinity to conventional NMDA receptors subtypes, but not to atypical subtypes that are relatively independent of voltage-dependent Mg2+-blockade. As has previously been reported, LTP, LTD, and depotentiation were all blocked by applications of D-AP5. In contrast, only LTP, but not LTD or depotentiation, was blocked by CPP. These observations suggest that decreases and increases of synaptic strength are mediated by the activation of distinct NMDA receptor subpopulations.

References

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Citations

Mar 17, 2009·Brain Topography·Lizbeth Cárdenas-MoralesCarlos Schönfeldt-Lecuona
May 24, 2011·Molecular Neurobiology·Frank Fetterolf, Kelly A Foster
Nov 20, 2004·Nature Reviews. Neuroscience·Graham L CollingridgeYu Tian Wang
Dec 4, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Olivia A Shipton, Ole Paulsen
Feb 12, 2013·Cerebral Cortex·Lizbeth Cárdenas-MoralesChristian Grefkes
Mar 21, 2007·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Ying-Zu HuangHsin-Yi Wen
Jun 10, 2014·Hippocampus·Sijie Zhang, Denise Manahan-Vaughan
Sep 21, 2013·Behavioural Brain Research·Nasrin HosseiniMohammad-Reza Zarrindast
Jun 30, 2012·Neuropharmacology·Sreedeep Mukherjee, Denise Manahan-Vaughan
Nov 2, 2014·Frontiers in Cellular Neuroscience·Alvaro O ArdilesAgustín D Martínez
Jun 9, 2004·Neurobiology of Learning and Memory·Sreedharan Sajikumar, Julietta U Frey
Nov 28, 2013·Pharmaceuticals·Zeynep Ates-Alagoz, Adeboye Adejare
Oct 5, 2018·Neurochemical Research·D LodgeA Volianskis

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