PMID: 2505198Jul 3, 1989Paper

Long-term potentiation and the induction of c-fos mRNA and proteins in the dentate gyrus of unanesthetized rats

Neuroscience Letters
M DragunowR L Faull

Abstract

We tested the hypothesis that the nuclear proto-oncogene c-fos is involved in long-term potentiation (LTP) of the perforant path-dentate gyrus synapse in awake freely moving rats. High-frequency stimulation that produced LTP induced c-fos mRNA and protein in the dentate granule cells but not in CA1, CA3, or the entorhinal cortex. However, the degree of LTP induction did not correlate with the degree of c-fos induction. Agents that interfered with the production of LTP (e.g. NMDA antagonists) also prevented c-fos induction. Low-frequency stimulation did not lead to either LTP or c-fos induction. However, c-fos induction did not necessarily follow LTP production because some high-frequency stimulation protocols that produced good LTP did not lead to c-fos induction. Thus, c-fos induction is clearly not related to LTP production in unanaesthetized rats, but it remains to be determined if it plays some role in LTP maintenance.

References

Aug 7, 1986·Nature·J I Morgan, T Curran
Nov 23, 1987·Neuroscience Letters·M Dragunow, H A Robertson

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Citations

Sep 24, 1999·Journal of Neuroscience Research·M WaltonM Dragunow
Jun 1, 1994·Annals of Neurology·A HandforthD M Treiman
Mar 1, 1993·Journal of Neuroscience Research·L Kaczmarek
Aug 1, 1993·Journal of Neuroscience Research·H Z ShengP G Nelson
Jan 1, 1991·Molecular Neurobiology·W C AbrahamW P Tate
Sep 17, 2009·Experimental Brain Research·Rie SugeBrian J McCabe
Apr 1, 1990·Pharmacology, Biochemistry, and Behavior·L WardW C Abraham
Sep 1, 1990·Behavioral and Neural Biology·W TischmeyerH Matthies
Aug 1, 1991·Brain Research. Molecular Brain Research·G C TeskeyD P Cain
Aug 1, 1991·Brain Research. Molecular Brain Research·M ClarkT Nakajima
Aug 1, 1991·Brain Research. Molecular Brain Research·S S SchreiberR F Thompson
Jun 1, 1992·Brain Research. Molecular Brain Research·F BilliaU De Boni
Aug 1, 1992·Brain Research. Molecular Brain Research·M BialyL Kaczmarek
Nov 1, 1992·Brain Research. Molecular Brain Research·L MassieuH W Boddeke
Mar 1, 1993·Brain Research. Molecular Brain Research·J DemmerW P Tate
Apr 1, 1993·Brain Research. Molecular Brain Research·C HeurteauxM Lazdunski
Jan 1, 1995·Brain Research. Molecular Brain Research·J WilliamsW Tate
Dec 28, 1995·Brain Research. Molecular Brain Research·P J MebergA Routtenberg
Jun 1, 1996·Brain Research. Molecular Brain Research·P J MebergA Routtenberg
May 31, 1990·Neuroscience Letters·M Dragunow, R L Faull
Mar 26, 1990·Neuroscience Letters·M Dragunow, R L Faull
Jan 20, 1992·Neuroscience Letters·A M Snyder-Keller, M G Pierson
Oct 1, 1993·Neuroscience Letters·M DragunowP Gluckman

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