Long-term potentiation expands information content of hippocampal dentate gyrus synapses

Proceedings of the National Academy of Sciences of the United States of America
Cailey BromerKristen M Harris

Abstract

An approach combining signal detection theory and precise 3D reconstructions from serial section electron microscopy (3DEM) was used to investigate synaptic plasticity and information storage capacity at medial perforant path synapses in adult hippocampal dentate gyrus in vivo. Induction of long-term potentiation (LTP) markedly increased the frequencies of both small and large spines measured 30 minutes later. This bidirectional expansion resulted in heterosynaptic counterbalancing of total synaptic area per unit length of granule cell dendrite. Control hemispheres exhibited 6.5 distinct spine sizes for 2.7 bits of storage capacity while LTP resulted in 12.9 distinct spine sizes (3.7 bits). In contrast, control hippocampal CA1 synapses exhibited 4.7 bits with much greater synaptic precision than either control or potentiated dentate gyrus synapses. Thus, synaptic plasticity altered total capacity, yet hippocampal subregions differed dramatically in their synaptic information storage capacity, reflecting their diverse functions and activation histories.

References

Apr 1, 1993·Trends in Neurosciences·J E Lisman, K M Harris
Jan 6, 2001·Journal of the American Medical Informatics Association : JAMIA·J C Fiala, K M Harris
Jun 2, 2001·Journal of Neurophysiology·J S SnyderJ M Wojtowicz
Aug 20, 2003·The Journal of Comparative Neurology·John C FialaKristen M Harris
Apr 9, 2005·Journal of Microscopy·J C Fiala
Nov 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Michael D SaxeMichael R Drew
Nov 24, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kristen M HarrisJamie Hurlburt
Jun 1, 2007·Journal of Neurophysiology·Wickliffe C AbrahamLubica Benuskova
Aug 3, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Christoph Schmidt-HieberJosef Bischofberger
Feb 16, 2008·Annual Review of Neuroscience·Natalia Caporale, Yang Dan
Dec 17, 2008·The Journal of Cell Biology·Irina NikonenkoDominique Muller
Mar 15, 2011·The European Journal of Neuroscience·Lucas A Mongiat, Alejandro F Schinder
Aug 9, 2011·Nature Neuroscience·Kenji MizusekiGyörgy Buzsáki
Aug 13, 2011·Neuron·Roland KrueppelHeinz Beck
Mar 14, 2012·Proceedings of the National Academy of Sciences of the United States of America·Enikö A KramárGary Lynch
Mar 17, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Joshua P Neunuebel, James J Knierim
Jun 13, 2012·Nature Methods·Stephan SaalfeldPavel Tomancak
Jun 23, 2012·PloS One·Albert CardonaRodney J Douglas
Jun 30, 2012·Nature Methods·Johannes SchindelinAlbert Cardona
Sep 14, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Alex H BabayanGary Lynch
Jun 21, 2013·The Journal of Comparative Neurology·Jennifer N BourneKristen M Harris
Feb 27, 2014·Nature Reviews. Neuroscience·György Buzsáki, Kenji Mizuseki
Apr 20, 2014·Neuron·Daniel MeyerVolker Scheuss
Jul 22, 2014·The Journal of Comparative Neurology·Maria Elizabeth BellKristen M Harris
Nov 28, 2014·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kechun Yang, John A Dani
Jan 13, 2015·Progress in Neurobiology·George KastellakisPanayiota Poirazi
Aug 2, 2015·Cell·Narayanan KasthuriJeff William Lichtman
Dec 1, 2015·ELife·Thomas M BartolTerrence J Sejnowski
Feb 10, 2016·Scientific Reports·Jeffrey Lopez-RojasMichael R Kreutz
Oct 6, 2016·Nature Communications·János Brunner, János Szabadics

❮ Previous
Next ❯

Citations

Jul 3, 2019·The Journal of Cell Biology·Justin H TrotterThomas C Südhof
Nov 7, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yuya SakimotoDai Mitsushima
Jul 22, 2020·ELife·Marta Montero-CrespoLidia Blazquez-Llorca
Nov 30, 2018·Frontiers in Neural Circuits·Yoshiyuki KubotaYasuo Kawaguchi
Sep 6, 2020·The European Journal of Neuroscience·Hongyu Zhang, Clive R Bramham
Feb 8, 2020·Biophysical Journal·Christopher T LeePadmini Rangamani
Jul 25, 2021·Proceedings of the National Academy of Sciences of the United States of America·Lea GoetzMichael Häusser

❮ Previous
Next ❯

Related Concepts

Related Feeds

BRAIN Initiative Cell Census Network (BICCN)

The BRAIN Initiative Cell Census Network aims to identify and provide experimental access to the different brain cell types to determine their roles in health and disease. Discover the latest research from researchers in the BRAIN Initiative Cell Census Network here.