PMID: 8606805Nov 1, 1995Paper

Long-term potentiation in mice lacking synapsins

Neuropharmacology
D SpillaneRobert C Malenka

Abstract

Synapsin I and synapsin II are widely expressed synaptic vesicle phosphoproteins that have been proposed to play an important role in synaptic transmission and synaptic plasticity. To gain further insight into the functional significance of the phosphorylation sites on the synapsins, we have examined a number of synaptic processes thought to be mediated by protein kinases in knockout mice lacking both forms of synapsin (Rosahl et al., 1995). Long-term potentiation (LTP) at both the mossy fiber (MF)-CA3 pyramidal cell synapse and the Schaffer collateral-CA1 pyramidal cell synapse appears normal in hippocampal slices prepared from mice lacking synapsins. Moreover, the effects on synaptic transmission of forskolin at MF synapses and H-7 at synapses on CA1 cells are also normal in the mutant mice. These results indicate that the synapsins are not necessary for: (1) the induction or expression of two different forms of LTP in the hippocampus, (2) the enhancement in transmitter release elicited by activation of the cAMP-dependent protein kinase (PKA) and (3) the depression of synaptic transmission caused by H-7. Although disappointing, these results are important in that they exclude the most abundant family of synaptic phosphoprotei...Continue Reading

References

Jan 1, 1992·Annual Review of Pharmacology and Toxicology·H Hidaka, R Kobayashi
Jan 1, 1991·Annual Review of Neuroscience·D V MadisonR A Nicoll
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·D MullerG Lynch
Nov 1, 1989·Trends in Pharmacological Sciences·A LaurenzaK B Seamon
Feb 1, 1988·Journal of Neurophysiology·W F Hopkins, D Johnston
Apr 16, 1987·Nature·M Bähler, P Greengard
Sep 1, 1987·The Journal of Cell Biology·T C Petrucci, J S Morrow
Jan 7, 1993·Nature·T V Bliss, G L Collingridge

❮ Previous
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Citations

Jun 5, 2003·European Journal of Pharmacology·Abdelkrim AllouiClaude Dubray
May 12, 1998·Pharmacology & Therapeutics·M Capogna
Aug 31, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ami Citri, Robert C Malenka
Sep 19, 2008·Proceedings of the National Academy of Sciences of the United States of America·Pascal S KaeserThomas C Südhof
Apr 17, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Ferenc Deak, William E Sonntag
Dec 8, 2011·Cold Spring Harbor Perspectives in Biology·Pablo E Castillo
Jan 1, 1997·Annual Review of Genetics·A J SilvaK P Giese
Apr 1, 1999·Annual Review of Physiology·R Fernández-Chacón, T C Südhof
Jun 16, 2006·Cell and Tissue Research·Susanne tom Dieck, Johann Helmut Brandstätter
Apr 14, 2011·The Journal of Physiology·Michael A Cousin, Gareth J O Evans
Jun 15, 2007·Biology of the Cell·Gareth J O Evans
Dec 23, 2009·Journal of Cellular Physiology·Silvia PegoraroVincent Torre
Sep 19, 2003·Biochemical and Biophysical Research Communications·James J CheethamLinda J Johnston
Jan 14, 2009·Hippocampus·Julius Paul Pradeep JohnGert Lubec
Aug 15, 2006·The European Journal of Neuroscience·Katherine G AkersAkaysha C Tang
Sep 29, 2004·Neuron·Robert C Malenka, Mark F Bear
Nov 1, 1996·Current Biology : CB·A J SilvaR Bourtchuladze
Oct 1, 1998·Neurobiology of Learning and Memory·A J SilvaJ H Kogan
Jun 3, 1999·The Journal of Cell Biology·S TeradaN Hirokawa
Jul 15, 1999·Nature Neuroscience·J R Sanes, J W Lichtman
Jan 5, 2005·Molecular Psychiatry·P García-Junco-ClementeR Fernández-Chacón
Aug 31, 2017·The Journal of Experimental Medicine·Lori KhrimianGerard Karsenty
Jan 18, 2002·Nature·Pablo E CastilloRobert C Malenka
Oct 28, 1998·Physiological Reviews·M R Picciotto, K Wickman
Jan 13, 2004·Physiological Reviews·M A Lynch
Aug 21, 2008·Journal of Cell Science·Anna CorradiFabio Benfenati

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