PMID: 9185686May 23, 1997Paper

Long-term potentiation in perforant path/granule cell synapses is associated with a post-synaptic induction of proenkephalin gene expression

Neuroscience Letters
L A RobertsB J Morris

Abstract

Enkephalin peptides released from hippocampal mossy fibres lower the threshold for the generation of long-term potentiation (LTP) at the mossy fibre synapses. High frequency stimulation of the hippocampal dentate gyrus, sufficient to induce mossy fibre LTP, is associated with increased expression of the proenkephalin gene in the granule cells. We show here that a similar elevation in proenkephalin mRNA levels is observed, in anaesthetised rats, following stimulation of the perforant path sufficient to induce LTP in the perforant path/granule cell synapses. This strengthens the evidence implicating granule cell enkephalins as mediators of functional plasticity in the hippocampus. Furthermore. the results hint at a form of 'domino plasticity', where potentiation of transmission at the perforant path/granule cell synapses is subsequently followed by an enkephalin-mediated potentiation of transmission at the mossy fibre synapses.

References

May 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·B J MorrisV Höllt
Aug 1, 1995·Trends in Neurosciences·B J Morris, H M Johnston
Jun 6, 1995·Proceedings of the National Academy of Sciences of the United States of America·W LinkD Kuhl
Jan 7, 1993·Nature·T V Bliss, G L Collingridge
Nov 1, 1996·Brain Research. Molecular Brain Research·L A RobertsB J Morris

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Citations

May 29, 1998·Brain Research. Molecular Brain Research·L A RobertsB J Morris

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