Long-term potentiation in the nucleus accumbens requires both NR2A- and NR2B-containing N-methyl-D-aspartate receptors

The European Journal of Neuroscience
Sietske M Schotanus, Karima Chergui

Abstract

N-methyl-d-aspartate (NMDA) receptors play crucial roles in several forms of long-term changes in the efficacy of glutamatergic synaptic transmission. The suggestion that the NR2A subunit of the NMDA receptor may be selectively involved in the induction of long-term potentiation (LTP) in the hippocampus and cortex has been challenged. However, the contribution of NR2B in the induction of LTP is not always clearly established. The present study investigates the role of NR2A and NR2B in the induction of LTP in the nucleus accumbens (NAc), a brain region that expresses high levels of NR2B and an NMDA-dependent form of LTP. We recorded extracellular field excitatory postsynaptic potentials/population spikes in slices of mouse NAc. High-frequency stimulation of glutamatergic fibers consistently induced LTP of the field excitatory postsynaptic potential/population spike in the NAc. LTP was abolished in the presence of selective antagonists of either NR2B [R-(R*,S*)-alpha-(4-hydroxyphenyl)-beta-methyl-4-(phenyl-methyl)-1-piperidine propanol and Ifenprodil] or NR2A ([(R)-[(S)-1-(4-bromo-phenyl)-ethylamino]-(2,3-dioxo-1,2,3,4-tetrahydroquinoxalin-5-yl)-methyl]-phosphonic acid) subunits. Recordings performed in a low concentration of Mg(...Continue Reading

References

Feb 1, 1993·The European Journal of Neuroscience·C M PennartzF H Lopes da Silva
May 1, 1994·The Journal of Comparative Neurology·D G StandaertJ B Penney
Sep 15, 1999·Nature·Y P TangJ Z Tsien
Mar 23, 2000·Progress in Neurobiology·P CalabresiG Bernardi
Jun 13, 2002·Proceedings of the National Academy of Sciences of the United States of America·David RobbeOlivier J Manzoni
Jul 19, 2002·Synapse·Nicole L SchrammDanny G Winder
Jan 11, 2003·Journal of Neurophysiology·David E ChapmanKaren S Wilcox
Apr 30, 2003·Journal of Neurochemistry·Anthone W Dunah, David G Standaert
May 13, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Mark J Thomas, Robert C Malenka
Sep 10, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Peter V MasseyZafar I Bashir
Sep 29, 2004·Neuron·Robert C Malenka, Mark F Bear
Oct 7, 2004·Neuropharmacology·Marina E WolfSteven Z Chao
Jul 15, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Karima CherguiPaul Greengard
Jul 22, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Sven BerberichGeorg Köhr
Sep 16, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Carl WeitlaufDanny G Winder
Feb 3, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jacques Neyton, Pierre Paoletti
Jun 17, 2006·Annual Review of Neuroscience·Steven E HymanEric J Nestler
Jul 25, 2006·Cell and Tissue Research·Georg Köhr
Aug 12, 2006·Neuropharmacology·Sven BerberichGeorg Köhr
Aug 18, 2006·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Caroline C Smith, Lori L McMahon

❮ Previous
Next ❯

Citations

May 24, 2011·Molecular Neurobiology·Frank Fetterolf, Kelly A Foster
Oct 27, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Jun WangDorit Ron
Oct 31, 2013·Proceedings of the National Academy of Sciences of the United States of America·Daniella RylanderBarbara Picconi
Jan 30, 2014·Progress in Neuro-psychopharmacology & Biological Psychiatry·Michal KrawczykEric C Dumont
Sep 6, 2015·Progress in Neuro-psychopharmacology & Biological Psychiatry·Elizabeth J BurnettHeather Trantham-Davidson
Mar 18, 2009·The European Journal of Neuroscience·James Edgar McCutcheon, Michela Marinelli
Jan 13, 2015·British Journal of Pharmacology·Milad Mohammadi, Markus Fendt
Apr 11, 2015·Frontiers in Cellular Neuroscience·Daniela NeuhoferOlivier J Manzoni
May 4, 2012·Alcoholism, Clinical and Experimental Research·Devesh MishraKarima Chergui
Nov 4, 2009·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Seung Hyun JeunKi-Wug Sung

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.