Long-term potentiation induced by single volley activation: a mechanism for bicuculline-induced enhancement of synaptic field potentials in the CA1 hippocampal region

Neuroscience
M PananceauB Gustafsson

Abstract

Long-term potentiation in the CA1 region is often evaluated as the change in the initial slope of the field response following a single test stimulus. This change is thought to represent an alteration of excitatory transmission only. However, it has recently been reported that this initial part of the field response is also controlled by a picrotoxin-resistant GABA(A)ergic response since bicuculline (100 microM), in the presence of picrotoxin, could lead to a substantial increase in the field response initial slope. A disinhibition may then be an important factor underlying expression of what is believed to be long-term potentiation of excitatory synaptic transmission. Alternatively, the bicuculline-induced field response enhancement could be due to an induction of long-term potentiation favoured by the low magnesium (1.25 mM) and high calcium (4 mM) concentrations used in these experiments. Results presented here show that neither picrotoxin (100 microM), nor bicuculline (100 microM), produce any significant change in field response initial slope, when examined using 4 mM magnesium and calcium in the perfusion fluid. In experiments using lower magnesium (1-1.5 mM), the same result was observed in most cases. In some cases, the...Continue Reading

References

May 18, 1979·Brain Research·R Dingledine, L Gjerstad
Sep 1, 1985·Acta Physiologica Scandinavica·H Wigström, B Gustafsson
Apr 1, 1994·Progress in Neurobiology·S M Thompson
Apr 12, 1994·Proceedings of the National Academy of Sciences of the United States of America·A StelzerR Rai

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Citations

Feb 26, 2014·Journal of Proteome Research·Pawel PalmowskiOle N Jensen
Feb 20, 2014·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Elisa S NaLisa M Monteggia
Jan 5, 2008·Movement Disorders : Official Journal of the Movement Disorder Society·Laura AvanzinoJohn C Rothwell
May 28, 2013·Neuropsychologia·Daniele OrtuDavid I Donaldson

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