PMID: 9159170May 27, 1997Paper

Long-term potentiation involves increases in the probability of neurotransmitter release

Proceedings of the National Academy of Sciences of the United States of America
P E Schulz

Abstract

There is great interest in understanding the mechanisms of expression underlying long-term potentiation (LTP). They are agreed to involve an increase in synaptic efficacy, which is described by three multiplicative parameters: p, the probability of neurotransmitter release; n, the number of active release sites; and q, the postsynaptic unit response to transmitter release. We report three new lines of evidence suggesting that increases in p contribute to LTP expression. (i) When the contributions to LTP by p, n, and q are maximized, and p alone is decreased, another high-frequency stimulation elicits additional LTP. The additional potentiation is only associated with decreases in paired-pulse facilitation (PPF) suggesting an increase in p. (ii) There is an inverse relationship between baseline p [corrected] and the magnitude of LTP elicited, consistent with p [corrected] having more or less room to increase when p is smaller or greater. (iii) It has been shown that there is an inverse relationship between the magnitude of LTP induced and the associated changes in PPF. Now I find that decreasing p before inducing LTP moves the set-point for measuring those changes in PPF from before to after p is decreased, which would only occu...Continue Reading

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Citations

May 10, 2001·Hippocampus·A M Kleschevnikov, A Routtenberg
Dec 12, 2003·Journal of Neuroscience Methods·Alexander E DityatevLeon L Voronin
Aug 9, 2003·Neuropharmacology·Leon L Voronin, Enrico Cherubini
Jun 20, 2000·Neuroscience·M VolgushevU T Eysel
Sep 19, 2003·Neural Networks : the Official Journal of the International Neural Network Society·Armen R SargsyanGeorge K Kostopoulos
Dec 21, 2000·The European Journal of Neuroscience·M VolgushevU T Eysel
Jun 26, 1999·The European Journal of Neuroscience·S TakahashiT Yagi
May 13, 2003·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Roger A Nicoll
Dec 4, 2013·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Zahid Padamsey, Nigel Emptage
Dec 4, 2012·International Journal of General Medicine·Kristen A BallesterosJoe L Martinez
Mar 23, 2004·The Journal of Physiology·Leon L Voronin, Enrico Cherubini
Jul 25, 2007·Progress in Neurobiology·S N SchiffmannS Ferré
Jan 9, 2007·Molecular and Cellular Neurosciences·Maolei XiaoDavid M Ornitz
Jun 26, 2003·The European Journal of Neuroscience·Alexander M Kleschevnikov, Aryeh Routtenberg
Jan 16, 2010·The European Journal of Neuroscience·Torfi SiguròssonJoseph E LeDoux
Sep 25, 2015·Nature Communications·Lorenza CianiPatricia C Salinas
Dec 31, 2005·Journal of Integrative Neuroscience·Sergi FerréRodrigo Cunha
Aug 9, 2018·PLoS Pathogens·Simote Totauhelotu FoliakiSteven John Collins
Dec 6, 2002·Journal of Neurophysiology·Michael V BarattaMelanie K Tallent
Mar 4, 2003·Journal of Neurophysiology·Paul E SchulzHenry F Epstein

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