Long-term potentiation of perforant path synapses in hippocampal CA1 in vitro

Brain Research
C M Colbert, W B Levy

Abstract

This paper reports a study of long-term potentiation (LTP) of perforant path synapses in CA1. Using rat hippocampal slices with CA3 and the dentate gyrus removed, stimulation of the perforant path evoked a population excitatory postsynaptic potential (pEPSP) that was negative-going in s. lacunosum-moleculare of CA1. High-frequency conditioning stimulation of the perforant pathway induced LTP of the perforant path pEPSP in slices disinhibited by the GABAA receptor antagonist bicuculline methiodide (20 microM). Conditioning of the perforant pathway in normal medium, however, failed to induce LTP. Potentiation of the perforant path pEPSP in the presence of bicuculline lasted at least 1 h, was specific to the tetanized pathway, and based on a threshold property, appeared associative in nature.

References

Oct 19, 1979·Brain Research·W B Levy, O Steward
Nov 24, 1978·Brain Research·B L McNaughtonG V Goddard
Oct 1, 1976·The Journal of Comparative Neurology·O Steward, S A Scoville
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·S R KelsoT H Brown
Dec 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G Barrionuevo, T H Brown
Nov 1, 1949·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·C O HEBB, H KONZETT

❮ Previous
Next ❯

Citations

Jul 29, 2011·Cellular and Molecular Life Sciences : CMLS·Rebecca A Piskorowski, Vivien Chevaleyre
Feb 24, 2016·Frontiers in Neural Circuits·Jossina GonzalezBrian E Derrick
Feb 28, 2014·The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry·Jian-Yi Xu, Chu Chen
Jul 19, 2002·Nature·Nace L GoldingNelson Spruston
May 1, 2007·The European Journal of Neuroscience·Sakura NakauchiKatumi Sumikawa
May 13, 2005·Journal of Neurophysiology·Nonna A OtmakhovaJohn E Lisman
Aug 24, 2013·Journal of Neurophysiology·Darrin H BragerDaniel Johnston
Jun 18, 2003·The Journal of Comparative Neurology·Verónica Martínez-CerdeñoFrancisco Clascá
Mar 23, 1999·Journal of Neurophysiology·H Dvorak-Carbone, E M Schuman
Jun 11, 2009·Neuroscience and Behavioral Physiology·I G Sil'kis
Jul 2, 2002·Journal of Neurophysiology·David B T McMahon, German Barrionuevo

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.