Long-term preservation of ischemic myocardium after experimental coronary artery occlusion

The Journal of Clinical Investigation
D MacleanP R Maroko

Abstract

The results of experiments with indirect methods have suggested that various interventions reduce infarct size after coronary artery occlusion. To determine and quantify directly both the short- and long-term effects of several interventions on myocardial salvage without relying on indirect methods, the left coronary artery was occluded in 880 rats; they were then given either no treatment or one of the following interventions: (a) hyaluronidase, an enzyme that hydrolyzes interstitial glycoproteins, 1,500 National Formulary (NF) U/kg i.v. 5 min and 24 h after occlusion; (b) cobra venom factor, a protein that depletes the third component of complement, 20 U/kg i.v. 5 min after occlusion; (c) a glucocorticoid: hydrocortisone, 50 mg/kg i.v. 5 min after occlusion; or the five-fold more potent methylprednisolone (MP): (i) 50 mg/kg i.v. 5 min after occlusion or (ii) 50 mg/kg i.v. 5 min after occlusion followed by 50 mg/kg i.m. 3, 6, and 24 h after occlusion; or (d) reserpine, an agent that depletes the heart of catecholamines, 0.5 mg/kg i.m. once on each of the 3 days before occlusion. The animals were sacrificed either 2 days after occlusion, i.e., at the time of peak necrosis, or after 3 wk, i.e., after the infarct was completely h...Continue Reading

References

Oct 8, 1976·Science·D MacleanE Braunwald
Nov 23, 1976·The American Journal of Cardiology·H K GoldP R Maroko
Mar 31, 1976·The American Journal of Cardiology·T N MastersF Robicsek
Nov 1, 1973·Annals of Internal Medicine·P R Maroko, E Braunwald
Mar 1, 1973·The Journal of Clinical Investigation·P LibbyE Braunwald
Feb 1, 1974·The American Journal of Medicine·B H Bulkley, W C Roberts
Nov 1, 1969·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Ballow, C G Cochrane
Jul 15, 1971·The New England Journal of Medicine·D L PageC A Sanders
Jul 1, 1970·British Heart Journal·C HanarayanB L Pentecost
Jan 1, 1967·Archives of Surgery·E Rehder, I F Enquist

❮ Previous
Next ❯

Citations

Jan 1, 1987·Virchows Archiv. A, Pathological Anatomy and Histopathology·P K KirchnerJ Schaper
Apr 1, 1981·The American Journal of Cardiology·R BolliS E Epstein
Jul 1, 1982·The American Journal of Cardiology·J S Hochman, B H Bulkley
Sep 1, 1979·American Journal of Surgery·J Ross
Sep 1, 1987·Progress in Cardiovascular Diseases·H F Weisman, B Healy
Aug 1, 1986·Journal of the Autonomic Nervous System·P H RatzS F Flaim
Jun 1, 1987·Journal of the Autonomic Nervous System·A K PeresR Zelis
Feb 1, 1994·Journal of the American College of Cardiology·P BélichardJ L Rouleau
Jan 1, 1988·Free Radical Biology & Medicine·S W Werns, B R Lucchesi
Jul 1, 1995·Cardiovascular Pathology : the Official Journal of the Society for Cardiovascular Pathology·C J CooperM A Pfeffer
Jan 1, 1996·Pharmacology & Therapeutics·F M Williams
Jul 1, 1986·Journal of the American College of Cardiology·H DrexlerR Zelis
Jan 1, 1986·Journal of the American College of Cardiology·B I Jugdutt, R W Amy
Apr 1, 1987·Journal of the American College of Cardiology·S W WernsB R Lucchesi
Oct 22, 2003·Pathophysiology : the Official Journal of the International Society for Pathophysiology·Robert P. OstrowskiAndrzej Kapuściński
Jun 4, 1998·Cardiovascular Surgery : Official Journal of the International Society for Cardiovascular Surgery·S P CavanaghS Homer-Vanniasinkam
Dec 22, 1999·The Journal of Experimental Medicine·M GriselliM B Pepys
Jun 1, 1979·British Journal of Clinical Pharmacology·D Maclean
Feb 1, 1979·Australian and New Zealand Journal of Medicine·P L Thompson
Nov 1, 1980·The Journal of Clinical Investigation·R N PinckardM S Olson
May 1, 1987·The Journal of Clinical Investigation·J A MannisiB Healy
Aug 1, 1989·The Journal of Clinical Investigation·M K Hostetter, G M Johnson
Jan 1, 1983·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·A J BogersL Hollaar
Sep 24, 2015·Journal of Cardiovascular Translational Research·William J Richardson, Jeffrey W Holmes
Jun 1, 1981·The American Journal of Cardiology·D J Hearse, D M Yellon
Feb 6, 1998·The Journal of Laboratory and Clinical Medicine·J R SilkensenM E Rosenberg
Mar 1, 1983·The American Journal of Cardiology·E J BrownE Braunwald
Aug 1, 1987·The American Journal of Cardiology·M T VivaldiF J Schoen
Oct 1, 1989·Prostaglandins, Leukotrienes, and Essential Fatty Acids·E F SmithJ W Egan
Jan 1, 1983·International Journal of Cardiology·M ChiarielloM Condorelli
Nov 1, 1983·American Heart Journal·R A Kloner, J A Kloner

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.