Long-term prognosis after childhood convulsive status epilepticus: a prospective cohort study

The Lancet Child & Adolescent Health
Suresh PujarNorth London Epilepsy Research Network

Abstract

The prognosis of convulsive status epilepticus (CSE), a common childhood medical neurological emergency, is not well characterised. We aimed to investigate the long-term outcomes in a cohort of participants who previously had CSE. In this prospective study, we followed up a population-based childhood CSE cohort from north London, UK (the north London convulsive status epilepticus surveillance study cohort; NLSTEPSS). We collected data from structured clinical neurological assessment, neurocognitive assessment (Wechsler Abbreviated Scale of Intelligence), brain MRI, medical records, and structured interviews with participants and their parents to determine neurological outcomes, with adverse outcome defined as presence of one or more of epilepsy (active or in remission), motor disability, intellectual disability, or statement of special educational needs. We applied multiple imputation to address missing data and performed binary logistic regression analyses on complete-case and imputed datasets to investigate sociodemographic and CSE factors associated with adverse outcomes. Of 203 survivors (90% of inception cohort), 134 (66%) were assessed at a median follow-up of 8·9 years (IQR 8·2-9·5). The cumulative incidence of epilepsy ...Continue Reading

Citations

Sep 5, 2019·Current Opinion in Pediatrics·Suresh Pujar, Rod C Scott
Aug 5, 2020·Developmental Medicine and Child Neurology·Leena D MewasinghRod C Scott
Sep 6, 2020·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Suchitra Joshi, Howard P Goodkin
Jul 3, 2020·Neurology·Iván Sánchez FernándezUNKNOWN pSERG
Nov 7, 2019·Current Opinion in Pediatrics·Suresh Pujar, Rod C Scott
Nov 3, 2020·Frontiers in Neuroscience·Katrina S EversSven Wellmann
Nov 7, 2020·Seminars in Neurology·Cristina Barcia AguilarTobias Loddenkemper
Feb 28, 2021·Seizure : the Journal of the British Epilepsy Association·Iván Sánchez FernándezMarina Gaínza-Lein
May 1, 2021·Developmental Medicine and Child Neurology·Clodagh MitchellJay Shetty
Apr 25, 2021·Neurology·Rod C Scott, Courtney J Wusthoff
Jun 1, 2021·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Li YangLan Zhang
Jul 13, 2021·Epilepsia·Marina Gaínza-LeinUNKNOWN Pediatric Status Epilepticus Research Group
Jun 13, 2020·Seizure : the Journal of the British Epilepsy Association·Klajdi PukaMark A Ferro

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