Long-term prognosis of childhood IgA nephropathy in adult life

Medicina clínica
G AricetaJ Rodríguez Soriano

Abstract

To evaluate long-term prognosis in a group of children with IgA nephropathy and to analyse which clinical factors were associated with progression to chronic renal failure in adulthood. Retrospective study. 58 young adults with IgA nephropathy diagnosed at 10.6(SD 2.9) years old and studied after a follow-up of 11.8 (SD 2.9) years. Relapses of macroscopic hematuria and proteinuria were the most frequent symptoms at onset (75.9%). In 25.9% of patients high plasmatic IgA levels were also detected. Most cases had grade I (44.8%)or grade II (44.8%) histological lesions at diagnosis. At the last control, clinical remision was observed in 21 patients (36.2%) and 50% of the whole group remained with abnormal urine. 8 patients(13.8%) reached terminal renal failure. Mean renal survival (defined as glomerular filtration rate above 50 ml/min/1.73 m2)was 100, 93.3 and 81.1% at 5, 10 and 15 years of evolution, respectively. About 14% of children with IgA nephropathy had long-term renal bad prognosis. Hypertension at onset, plasma creatinine elevation and proteinuria during adolescence were significant risk factors associated with chronic renal failure during adulthood. Minimal lesions at IgA nephropathy diagnosis in children did not exclude...Continue Reading

Citations

Jul 4, 2012·International Journal of Nephrology·M Colleen HastingsRobert J Wyatt
Jul 14, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Jaana RonkainenMatti Nuutinen
Oct 19, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Keith K LauJan Novak
Mar 12, 2008·Current Opinion in Pediatrics·John T Sanders, Robert J Wyatt
May 25, 2004·Seminars in Nephrology·Noel M Delos Santos, Robert J Wyatt

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