Long-term prognosis of combined chronic heart failure and chronic renal dysfunction after acute stroke

European Journal of Heart Failure
George TsagalisKonstantinos N Vemmos

Abstract

To assess the prevalence of combined chronic heart failure and chronic renal dysfunction (CHF-CRD) in acute stroke patients and to investigate any prognostic significance on long-term outcome. First-ever acute stroke patients (n = 831) were divided into four groups based on the presence of heart failure (HF, NYHA II-IV with or without left ventricular ejection fraction <40%) and/or renal dysfunction (RD, estimated glomerular filtration rate <60 mL/min/1.73 m(2)). Patients with acute kidney injury and/or acute decompensated HF were excluded. Group 1 comprised patients without HF or RD (nHF + nRD), Group 2 patients with RD but no HF (nHF + RD), Group 3 those with HF and no RD (HF + nRD), whereas Group 4 included patients with both HF and RD (HF + RD). HF and RD were independent predictors of mortality at 10 years. Patients in Groups 2, 3, and 4 had an increased probability of death during follow-up compared with Group 1: HR 1.34 (95% CI 1.02-1.77, P < 0.05) for group 2; HR 2.24 (95% CI 1.50-3.36, P < 0.001) for group 3; and HR 3.42 (95% CI 2.36-4.95, P < 0.001) for group 4. Age, history of transient ischaemic attacks and combined HF and RD were independent predictors of new cardiovascular events. When compared with Group 1, patie...Continue Reading

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Citations

Jan 5, 2011·Heart Failure Reviews·Dinna N CruzSean M Bagshaw
Mar 6, 2016·Journal of the Neurological Sciences·Aristeidis H KatsanosGeorgios Tsivgoulis
Mar 14, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Anne RowatMartin Dennis
Jan 1, 2014·Australasian Journal on Ageing·Chia-Yu HsuYu-Ning Hu
May 9, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Fabio FabbianRoberto Manfredini
Aug 8, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Anetta Lasek-BalJan Duława

Related Concepts

Acute Disease
Health Status Indicators
Heart Diseases
Myocardial Failure
Kidney Failure, Chronic
Stroke Volume
Comorbidity
Multivariate Analysis
Confidence Intervals
Cox Proportional Hazards Models

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