Long-term prognosis of combined chronic heart failure and chronic renal dysfunction after acute stroke

European Journal of Heart Failure
George TsagalisKonstantinos N Vemmos


To assess the prevalence of combined chronic heart failure and chronic renal dysfunction (CHF-CRD) in acute stroke patients and to investigate any prognostic significance on long-term outcome. First-ever acute stroke patients (n = 831) were divided into four groups based on the presence of heart failure (HF, NYHA II-IV with or without left ventricular ejection fraction <40%) and/or renal dysfunction (RD, estimated glomerular filtration rate <60 mL/min/1.73 m(2)). Patients with acute kidney injury and/or acute decompensated HF were excluded. Group 1 comprised patients without HF or RD (nHF + nRD), Group 2 patients with RD but no HF (nHF + RD), Group 3 those with HF and no RD (HF + nRD), whereas Group 4 included patients with both HF and RD (HF + RD). HF and RD were independent predictors of mortality at 10 years. Patients in Groups 2, 3, and 4 had an increased probability of death during follow-up compared with Group 1: HR 1.34 (95% CI 1.02-1.77, P < 0.05) for group 2; HR 2.24 (95% CI 1.50-3.36, P < 0.001) for group 3; and HR 3.42 (95% CI 2.36-4.95, P < 0.001) for group 4. Age, history of transient ischaemic attacks and combined HF and RD were independent predictors of new cardiovascular events. When compared with Group 1, patie...Continue Reading


Feb 1, 1991·Journal of Internal Medicine·P J Friedman
Jul 1, 1989·Stroke; a Journal of Cerebral Circulation·T BrottV Hertzberg
Feb 25, 2000·Cerebrovascular Diseases·K N VemmosS Stamatelopoulos
Jun 8, 2002·Stroke; a Journal of Cerebral Circulation·Ronald S MacWalterRouling Chen
Dec 25, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Josef CoreshAndrew S Levey
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Jun 3, 2006·Stroke; a Journal of Cerebral Circulation·Allison G HaysMarco R Di Tullio
Nov 9, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Adrian CovicNorica Posta
Feb 6, 2008·Intensive Care Medicine·Claudio RoncoMikko Haapio
Aug 30, 2008·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·George TsagalisKonstantinos N Vemmos
Feb 3, 2009·Stroke; a Journal of Cerebral Circulation·Gilad YahalomDavid Tanne
Feb 13, 2009·Clinical Journal of the American Society of Nephrology : CJASN·George TsagalisKonstantinos N Vemmos


Jan 5, 2011·Heart Failure Reviews·Dinna N CruzSean M Bagshaw
Mar 6, 2016·Journal of the Neurological Sciences·Aristeidis H KatsanosGeorgios Tsivgoulis
Mar 14, 2014·International Journal of Stroke : Official Journal of the International Stroke Society·Anne RowatMartin Dennis
Jan 1, 2014·Australasian Journal on Ageing·Chia-Yu HsuYu-Ning Hu
May 9, 2012·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Fabio FabbianRoberto Manfredini
Aug 8, 2014·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Anetta Lasek-BalJan Duława

Related Concepts

Acute Disease
Health Status Indicators
Heart Diseases
Myocardial Failure
Kidney Failure, Chronic
Stroke Volume
Multivariate Analysis
Confidence Intervals
Cox Proportional Hazards Models

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