PMID: 11929710Apr 4, 2002Paper

Long-term prognosis of primary biliary cirrhosis (PBC) in Japan and analysis of the factors of stage progression in asymptomatic PBC (a-PBC)

Hepatology Research : the Official Journal of the Japan Society of Hepatology
Toshiaki NakanoGotaro Toda

Abstract

Objective: Based on data from a national survey of primary biliary cirrhosis (PBC), the pathology and prognosis of PBC in Japan were clarified. In particular, we tried to perform multivariate analysis of factors useful in determining prognosis of asymptomatic PBC (a-PBC). Methods: The survey was performed 10 times. Responses from 3778 of 4361 registered patients (416 institutions) were investigated (survey period: January 1968-December 1998). At the time of diagnosis, patients were classified as a-PBC or symptomatic PBC (s1-PBC; pruritus only, s2-PBC; jaundice and serum bilirubin level above 2 mg/dl). The survival rate was obtained by the Kaplan-Meier method. Logistic regression analysis was used in multivariate analysis of prognostic factors of a-PBC. Results: There were no significant differences in clinical findings from those in previous reports. The 5-year survival rates of patients with a-PBC, s1-PBC, and s2-PBC at the time of diagnosis were 97, 88, and 53%, respectively. Patients with a-PBC at the time of diagnosis were divided into groups: those in whom the disease progressed to s2-PBC (8%) and did not progress to s2-PBC (92%) at the final examination, and the prognosis was compared between groups. The prognosis was sig...Continue Reading

Citations

Jul 27, 2007·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Marion G PetersUNKNOWN PUMPS Group
Dec 1, 2012·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Kenichi HaradaYasuni Nakanuma
Sep 13, 2003·World Journal of Gastroenterology : WJG·Xiao-Hua JiangXian-Tao Kong
Jan 25, 2008·Orphanet Journal of Rare Diseases·Teru Kumagi, E Jenny Heathcote
Aug 19, 2008·Journal of Gastroenterology·Yosuke MurataMorikazu Onji
Aug 8, 2008·Scandinavian Journal of Rheumatology·K TakadaF Ohsuzu
Jul 16, 2009·Seminars in Immunopathology·Simon HohenesterUlrich Beuers
Feb 1, 2011·Cellular & Molecular Immunology·Francesca MedaCarlo Selmi
Sep 14, 2011·Expert Review of Gastroenterology & Hepatology·Nelson ChuangJoseph A Odin
Feb 7, 2018·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Atsushi TanakaUNKNOWN Japan PBC Study Group (JPBCSG)
Oct 10, 2013·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Kenichi Harada, Yasuni Nakanuma
Jan 9, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·UNKNOWN Working Subgroup (English version) for Clinical Practice Guidelines for Primary Biliary Cirrhosis
May 9, 2008·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Masanori Abe, Morikazu Onji
Apr 4, 2015·World Journal of Gastroenterology : WJG·Xue-Xiu ZhangFu-Sheng Wang
Jan 8, 2011·Internal Medicine·Hiromi IshibashiMinoru Nakamura
Mar 28, 2013·Gastroenterology Research and Practice·Kenichi HosonumaMasatomo Mori
Apr 22, 2021·Journal of Hepatology·Atsushi TanakaChristophe Corpechot

❮ Previous
Next ❯

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.