Long-term prognosis of steroid-dependent sensorineural hearing loss

Audiology & Neuro-otology
Jin KanzakiKaoru Ogawa

Abstract

We report on the long-term follow-up of 15 patients with steroid-dependent sensorineural hearing loss (SDSNHL), which was steroid dose dependent. We classified the patients into 2 groups: group A consisted of 6 patients with systemic SDSNHL, and group B consisted of 9 patients with inner-ear-specific SDSNHL without systemic disease. Group B patients were further classified as patients with slowly or rapidly progressive hearing loss. The yearly rate of hearing deterioration was greater in group B than in group A. Thus, the long-term hearing prognosis of patients in group B was worse than those in group A. Although SDSNHL may have immune-related origins, we hypothesize that hearing deterioration may be caused by proinflammatory cytokines because many of our cases exhibited abnormal immunological laboratory values and because many of these cases responded favorably to steroid treatment.

Citations

Aug 10, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery·Dennis R Trune
Oct 10, 2012·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Dennis R Trune, Barbara Canlon
Oct 21, 2015·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Jason A BrantMichael J Ruckenstein
Aug 9, 2012·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Masatsugu MasudaKaoru Ogawa
Sep 10, 2010·Current Opinion in Otolaryngology & Head and Neck Surgery

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