Long-term prognostic impact of surgical complications in the German Rectal Cancer Trial CAO/ARO/AIO-94

The British Journal of Surgery
Thilo SprengerMichael Ghadimi

Abstract

The influence of postoperative complications on survival in patients with locally advanced rectal cancer undergoing combined modality treatment is debatable. This study evaluated the impact of surgical complications on oncological outcomes in patients with locally advanced rectal cancer treated within the randomized CAO/ARO/AIO-94 (Working Group of Surgical Oncology/Working Group of Radiation Oncology/Working Group of Medical Oncology of the Germany Cancer Society) trial. Patients were assigned randomly to either preoperative chemoradiotherapy (CRT) followed by total mesorectal excision (TME) or postoperative CRT between 1995 and 2002. Anastomotic leakage and wound healing disorders were evaluated prospectively, and their associations with overall survival, and distant metastasis and local recurrence rates after a long-term follow-up of more than 10 years were determined. Medical complications (such as cardiopulmonary events) were not analysed in this study. A total of 799 patients were included in the analysis. Patients who had anterior or intersphincteric resection had better 10-year overall survival than those treated with abdominoperineal resection (63·1 versus 51·3 per cent; P < 0·001). Anastomotic leakage was associated w...Continue Reading

References

Mar 1, 1992·Diseases of the Colon and Rectum·P GertschH J Altermatt
Nov 1, 1991·International Journal of Colorectal Disease·A M AkyolW D George
Apr 8, 1998·The British Journal of Surgery·E RullierM Parneix
Nov 12, 1998·International Journal of Colorectal Disease·S PetersenK Ludwig
Nov 21, 1998·Diseases of the Colon and Rectum·D C JennerM D Levitt
Apr 3, 1999·British Journal of Cancer·R AbramovitchM Neeman
Mar 7, 2001·Lancet·F Balkwill, A Mantovani
Jun 7, 2003·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·S MerkelP Hermanek
Oct 22, 2004·The New England Journal of Medicine·Rolf SauerUNKNOWN German Rectal Cancer Study Group
Nov 13, 2004·Diseases of the Colon and Rectum·Koutarou MaedaYoshimune Horibe
Sep 2, 2005·Annals of Surgery·Shukri F KhuriUNKNOWN Participants in the VA National Surgical Quality Improvement Program
Feb 24, 2006·The British Journal of Surgery·P MatthiessenR Sjödahl
Mar 29, 2007·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Wai Lun LawChi Leung Seto
Aug 3, 2007·The British Journal of Surgery·H PtokUNKNOWN Study Group Colon/Rectum Carcinoma (Primary Tumour)
Dec 12, 2007·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·A A KhanN J McC Mortensen
Oct 18, 2011·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Jen-Kou LinTzu-Chen Lin
Apr 25, 2012·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Rolf SauerClaus Rödel
Jan 10, 2014·Diseases of the Colon and Rectum·Alexander T HawkinsLiliana Bordeianou
Jan 27, 2015·The British Journal of Surgery·E EspínUNKNOWN Spanish Rectal Cancer Project

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Citations

Nov 15, 2018·Colorectal Disease : the Official Journal of the Association of Coloproctology of Great Britain and Ireland·N de'AngelisUNKNOWN EuMaRCS Study Group
Apr 22, 2020·International Journal of Colorectal Disease·Hiroshi HasegawaYoshihiro Kakeji
Aug 31, 2020·The Journal of International Medical Research·Lei NiuXiaomu Zhao
Jun 23, 2020·Clinical and Translational Gastroenterology·Maria CambrayE Guinó

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