Long-term prognostic performance of low-dose coronary computed tomography angiography with prospective electrocardiogram triggering

European Radiology
Olivier F ClercRonny R Buechel

Abstract

To assess long-term prognosis after low-dose 64-slice coronary computed tomography angiography (CCTA) using prospective electrocardiogram-triggering. We included 434 consecutive patients with suspected or known coronary artery disease referred for low-dose CCTA. Patients were classified as normal, with non-obstructive or obstructive lesions, or previously revascularized. Coronary artery calcium score (CACS) was assessed in 223 patients. Follow-up was obtained regarding major adverse cardiac events (MACE): cardiac death, myocardial infarction and elective revascularization. We performed Kaplan-Meier analysis and Cox regressions. Mean effective radiation dose was 1.7 ± 0.6 mSv. At baseline, 38% of patients had normal arteries, 21% non-obstructive lesions, 32% obstructive stenosis and 8% were revascularized. Twenty-nine patients (7%) were lost to follow-up. After a median follow-up of 6.1 ± 0.6 years, MACE occurred in 0% of patients with normal arteries, 6% with non-obstructive lesions, 30% with obstructive stenosis and 39% of those revascularized. MACE occurrence increased with increasing CACS (P < 0.001), but 4% of patients with CACS = 0 experienced MACE. Multivariate Cox regression identified obstructive stenosis, lesion burden...Continue Reading

References

Nov 6, 2001·Journal of the American College of Cardiology·T H MarwickM Lauer
Aug 10, 2006·European Journal of Nuclear Medicine and Molecular Imaging·Tiziano SchepisPhilipp A Kaufmann
Dec 20, 2007·European Heart Journal·Lars HusmannPhilipp A Kaufmann
Aug 12, 2008·The American Journal of Medicine·Paul D SteinH Dirk Sostman
Oct 22, 2008·Journal of the American College of Cardiology·Matthew P OstromMatthew J Budoff
Feb 5, 2009·JAMA : the Journal of the American Medical Association·Jörg HausleiterStephan Achenbach
Feb 24, 2009·AJR. American Journal of Roentgenology·Fuminari TatsugamiPhilipp A Kaufmann
Jun 13, 2009·JACC. Cardiovascular Imaging·Ammar SarwarKhurram Nasir
Jul 4, 2009·Journal of the American College of Cardiology·Bernhard A HerzogPhilipp A Kaufmann
Apr 29, 2010·JAMA : the Journal of the American Medical Association·Tamar S PolonskyPhilip Greenland
Dec 15, 2010·Journal of the American College of Cardiology·Edward A HultenTodd C Villines
Dec 28, 2010·The American Journal of Cardiology·Fabiola B SozziVincent Dor
Jan 15, 2011·Journal of the American College of Cardiology·Ronny R BuechelPhilipp A Kaufmann
Jul 14, 2012·JACC. Cardiovascular Imaging·Daniele AndreiniMauro Pepi
Aug 28, 2012·European Heart Journal·Kristian ThygesenUNKNOWN ESC Committee for Practice Guidelines (CPG)
Apr 9, 2014·The International Journal of Cardiovascular Imaging·Svetlana DougoudOliver Gaemperli
Aug 22, 2015·International Journal of Cardiology·Young Joo SuhByoung Wook Choi
Oct 12, 2015·The International Journal of Cardiovascular Imaging·Jonathan NadjiriMartin Hadamitzky

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Citations

Jun 9, 2019·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Dominik C Benz, Andreas A Giannopoulos
Jan 3, 2020·The International Journal of Cardiovascular Imaging·Georgios BenetosChristoph Gräni
Aug 14, 2020·AJR. American Journal of Roentgenology·Gorka BastarrikaGregorio Rábago
Aug 7, 2020·AJR. American Journal of Roentgenology·Kevin M Johnson, David A Dowe
Aug 29, 2021·Trends in Cardiovascular Medicine·David I FeldmanArmin Arbab-Zadeh

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