Long-term Progression and Risk Factors of Fundus Tessellation in the Beijing Eye Study

Scientific Reports
Yan Ni YanJost B Jonas

Abstract

To assess the progression of fundus tessellation, color fundus photographs of the participants of the longitudinal population-based Beijing Eye Study were examined. The study included 4439 subjects in 2001 and 2695 (66.4% of the surviving) individuals in 2011. Larger progression in macular fundus tessellation (mean: 0.24 ± 0.48 grades) was associated (multivariate analysis; correlation coefficient r: 0.53) with thinner subfoveal choroidal thickness in 2011 (P < 0.001; standardized regression coefficient beta: -0.37), older age (P < 0.001; beta: 0.22), higher level of education (P < 0.001; beta: 0.09), more myopic change in refractive error (P < 0.001; beta: -0.09) and lower cognitive function score (P = 0.02; beta: -0.05). Larger increase in peripapillary fundus tessellation (mean: 0.19 ± 0.26 grades) correlated with thinner peripapillary choroidal thickness in 2011 (P < 0.001; beta: -0.35), older age (P < 0.001; beta: 0.20), worse best corrected visual acuity (P = 0.001; beta: 0.07), more myopic change in refractive error (P < 0.001; beta: -0.07) and higher prevalence of ever smoking (P = 0.004; beta: 0.05). The increase in macular fundus tessellation, as a surrogate for thinning of the posterior choroid, was associated with l...Continue Reading

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Citations

Mar 24, 2020·Ophthalmic Genetics·Lavinia PostolacheGeorges Casimir
Apr 17, 2020·Investigative Ophthalmology & Visual Science·Yee-Ling WongSeang-Mei Saw
Jun 9, 2020·Investigative Ophthalmology & Visual Science·Sidi WangZhikuan Yang
Sep 29, 2019·Investigative Ophthalmology & Visual Science·Yin GuoLijuan Wu
Apr 27, 2021·Frontiers in Cell and Developmental Biology·Li DongWen Bin Wei

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