PMID: 6537955Mar 1, 1984Paper

Long-term prostaglandin E1 therapy in congenital heart defects

Journal of the American College of Cardiology
O H TeixeiraP Vlad

Abstract

Seventeen neonates received an intravenous infusion of prostaglandin E1 for an average of 39 days (range 8 to 104). Seven (group 1) had transposition of the great arteries with no ventricular septal defect or a small one; eight (group 2) had ductus-dependent pulmonary flow (pulmonary atresia or stenosis in six and tricuspid atresia in two); and two (group 3) had aortic coarctation, one with no ventricular septal defect, the other with ventricular septal defect, isthmus hypoplasia and descending aortic flow supplied mainly by the ductus. An increase in the arterial partial pressure of oxygen (PO2) was seen in groups 1 and 2. Six patients from group 1 and two from group 2 developed heart failure; cortical hyperostosis of long bones was seen in three patients from group 1 and three from group 2; one from group 1 had refractory diarrhea. Other side effects seen at the beginning improved as the rate of infusion diminished. In group 3, the patient with complex coarctation had a decrease in blood pressure in the arms, an increase in pressure in the legs and restoration of renal function; in the patient with no ventricular septal defect, heart failure worsened during therapy. Histologic changes seen in three ductus were attributed to t...Continue Reading

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Citations

Jan 1, 1985·Skeletal Radiology·A K PoznanskiT E Berry
Mar 18, 2000·Pediatric Dermatology·E L Carter, M C Garzon
Sep 1, 1995·European Journal of Pediatrics·H H KramerO Krogmann
Aug 12, 2015·Pediatric Cardiology·Alper AykanatGüner Karatekin
Nov 1, 1991·International Journal of Cardiology·A KorulaJ M Neutze
Jan 1, 1988·The Journal of Surgical Research·R S WalshR M Mentzer
Mar 30, 2001·The Journal of Thoracic and Cardiovascular Surgery·P M VerheijenG B Bennink
Dec 1, 1993·The American Journal of Cardiology·D IvyM Schaffer
Feb 28, 2018·The Cochrane Database of Systematic Reviews·Smita AkkinapallyMohan Pammi
Apr 5, 2020·The Annals of Thoracic Surgery·Ryuma IwakiYoshihiro Oshima

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