Long-term quality of life and risk factors for recurrence after laparoscopic repair of paraesophageal hernia

JAMA Surgery
Anne O LidorMichael R Marohn

Abstract

Laparoscopic repair of paraesophageal hernia (PEH) has been shown to result in excellent relief of symptoms and improved quality of life (QOL) despite a relatively high radiographically identified recurrence rate. To assess potential risk factors for recurrence and long-term change in QOL after laparoscopic repair of PEH. This was a prospective study of 111 patients who underwent elective laparoscopic repair of type III PEH with biological mesh buttressed over a primary cruroplasty from April 3, 2009, through July 31, 2014, at the Department of Surgery, Johns Hopkins University of Medicine. We administered a modified version of a validated gastroesophageal reflux disease-specific QOL tool to patients before and at 2, 12, and 36 months after the procedure. Higher QOL scores represent greater severity of symptoms. An upper gastrointestinal tract barium-contrast radiographic examination was performed at 1 year to assess for recurrence. Demographic factors, comorbidities, and preoperative radiographic findings were analyzed as possible indicators for recurrence using logistic regression. Quality of life, measured by the gastroesophageal reflux disease-specific QOL tool, and recurrence, defined as a PEH of greater than 2 cm. Median ...Continue Reading

Associated Clinical Trials

Citations

Aug 6, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Rym El KhouryMarco G Patti
Sep 7, 2016·Current Gastroenterology Reports·Jessica A Zaman, Anne O Lidor
Nov 23, 2016·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Tyler D Cohn, Nathaniel J Soper
Feb 8, 2019·Surgical Laparoscopy, Endoscopy & Percutaneous Techniques·Connal Robertson-MoreEstifanos Debru
May 20, 2020·Arquivos Brasileiros De Cirurgia Digestiva : ABCD = Brazilian Archives of Digestive Surgery·Italo BraghettoManuel Figueroa
Sep 21, 2019·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Vijay KorwarAudun Sigurdsson
Oct 4, 2017·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Oliver C BellevueRalph W Aye
Nov 5, 2019·World Journal of Gastrointestinal Surgery·Bernabé M Quesada, Adelina E Coturel
Apr 24, 2019·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Dominic R ParkerDavid I Watson
Jul 28, 2019·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Cheng ChengFan Lv
Apr 27, 2020·Hernia : the Journal of Hernias and Abdominal Wall Surgery·A AiolfiD Bona
Oct 9, 2020·Surgical Endoscopy·Colin P DunnJohn C Lipham
Aug 15, 2021·Advances in Surgery·Laura Mazer, Dana A Telem
Apr 23, 2021·Journal of Minimal Access Surgery·Akshay R DateRavindra S Date

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.