Long-term reaction to bone cement in osteoporotic bone: new bone formation in vertebral bodies after vertebroplasty.

Journal of Anatomy
Volker BraunsteinStefan Milz

Abstract

Elderly patients frequently suffer from osteoporotic vertebral fractures resulting in the need of vertebroplasty or kyphoplasty. Nevertheless, no data are available about the long-term consequences of cement injection into osteoporotic bone. Therefore, the aim of the present study was to evaluate the long-term tissue reaction on bone cement injected to osteoporotic bone during vertebroplasty. The thoracic spine of an 80-year-old female was explanted 3.5 years after vertebroplasty with polymethylmethacrylate. The treatment had been performed due to painful osteoporotic compression fractures. Individual vertebral bodies were cut in axial or sagittal sections after embedding. The sections were analysed using contact radiography and staining with toluidine blue. Furthermore, selected samples were evaluated with scanning electron microscopy and micro-compted tomography (in-plane resolution 6 microm). Large amounts of newly formed callus surrounding the injected polymethylmethacrylate were detected with all imaging techniques. The callus formation almost completely filled the spaces between the vertebral endplate, the cancellous bone, and the injected polymethylmethacrylate. In trabecular bone microfractures and osteoclast lacuna wer...Continue Reading

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Citations

Aug 4, 2011·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Sophie VerrierAndreas Boger
Nov 8, 2013·Journal of Neurointerventional Surgery·Ronil V ChandraUNKNOWN Society of NeuroInterventional Surgery
Oct 28, 2010·Physical Medicine and Rehabilitation Clinics of North America·Nayna Patel
Jul 28, 2016·Archives of Orthopaedic and Trauma Surgery·Stephan F SchindeleStefanie Hensler
Jun 27, 2018·Journal of Korean Neurosurgical Society·Ihab ZidanAmr Elwany
Dec 16, 2020·ACS Biomaterials Science & Engineering·Rita GelliFrancesca Ridi

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