Long-term rebamipide and diquafosol in two cases of immune-mediated dry eye

Optometry and Vision Science : Official Publication of the American Academy of Optometry
Mio YamaneKazuo Tsubota

Abstract

Two new drugs with mucin-inducing and secretion-promotive effects, rebamipide and diquafosol, were recently approved as topical dry-eye treatments. We report two cases in which the long-term use of mucin-inducing eye drops improved chronic ocular graft-versus-host disease (cGVHD)-related dry eye and ocular cicatricial pemphigoid (OCP)-like disease. Case 1. A 61-year-old woman had cGVHD-related dry eye that resisted traditional medications. Next, we use topical diquafosol in addition to conventional treatments. The patient used diquafosol for 6 months without experiencing any side effects. The symptoms, including dry-eye sensation, ocular pain, foreign body sensation, and photophobia, as well as ocular surface findings including fluorescein and rose bengal scores and tear break-up time (TBUT), partly improved. To further improve the clinical signs and symptoms and decrease chronic inflammation, rebamipide was added to diquafosol. The symptoms, TBUT, and fluorescein and rose bengal scores markedly improved after long-term dual treatment without any side effects for 6 months. Case 2. A 77-year-old woman had OCP-like disease with dry eye. The patient did not improve using the currently available conventional treatments. Next, we us...Continue Reading

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Citations

Nov 1, 2015·Neuropharmacology·Ivar von Kügelgen, Kristina Hoffmann
Nov 28, 2018·Investigative Ophthalmology & Visual Science·Yoko Ogawa
Nov 28, 2018·Investigative Ophthalmology & Visual Science·Minako Kaido
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Aug 20, 2019·Eye & Contact Lens·Kazuo TsubotaUNKNOWN Members of The Asia Dry Eye Society
Jun 17, 2020·Molecular Imaging·Hamideh Zarrinmayeh, Paul R Territo
Apr 30, 2021·Indian Journal of Ophthalmology·Sridevi NairYoko Ogawa
Jun 28, 2021·Biomedical Journal·Mariana M ChavesRobson Coutinho-Silva
Jul 3, 2021·International Journal of Molecular Sciences·Yoko OgawaKazuo Tsubota

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