Long-term reciprocal changes in dopamine levels in prefrontal cortex versus nucleus accumbens in rats born by Caesarean section compared to vaginal birth

Experimental Neurology
B F El-Khodor, P Boksa

Abstract

Epidemiological evidence indicates a higher incidence of pregnancy and birth complications among individuals who later develop schizophrenia, a disorder linked to alterations in mesolimbic dopamine (DA) function. Two birth complications usually included in these epidemiological studies, and still frequently encountered in the general population, are birth by Caesarean section (C-section) and fetal asphyxia. To test the hypothesis that birth complications can produce long-lasting changes in DA systems, the present study examined the effects of Caesarean birth, with or without an added period of anoxia, on steady state monoamine levels and metabolism in various brain regions in a rat model. Pups born vaginally served as controls. At 2 months of age, in animals born by rapid C-section, steady state levels of DA were decreased by 53% in the prefrontal cortex and increased by 40% in both the nucleus accumbens and striatum, in comparison to the vaginally born group. DA turnover increased in the prefrontal cortex, decreased in the nucleus accumbens, and showed no significant change in the striatum, in the C-section group. Thus, birth by a Caesarean procedure produces long-term reciprocal changes in DA levels and metabolism in the nucl...Continue Reading

References

Mar 1, 1978·Pediatric Research·D V Walters, R E Olver
Mar 1, 1992·Birth·S M TaffelC L Kosary
Nov 1, 1991·The American Journal of Psychiatry·K L DavisM Davidson
Jul 1, 1991·American Journal of Respiratory Cell and Molecular Biology·J H FisherT Hofmann
Jan 1, 1985·The Journal of Physiology·F J Seidler, T A Slotkin
Jul 1, 1987·Archives of General Psychiatry·D R Weinberger
Oct 1, 1985·Analytical Biochemistry·P K SmithD C Klenk
Apr 1, 1986·Scientific American·H Lagercrantz, T A Slotkin
Apr 1, 1972·The Journal of Physiology·R S Comline, M Silver
Apr 1, 1984·Annals of Neurology·F Silverstein, M V Johnston
May 1, 1983·Journal of Neurochemistry·W A Pulsinelli, T E Duffy
Sep 12, 1995·Proceedings of the National Academy of Sciences of the United States of America·B K Lipska, D R Weinberger
Jan 1, 1993·Journal of Neurochemistry·A PastuszkoM Delivoria-Papadopoulos
Oct 1, 1993·International Journal of Gynaecology and Obstetrics : the Official Organ of the International Federation of Gynaecology and Obstetrics·K A HalesG R Thurnau
Feb 1, 1994·The British Journal of Psychiatry : the Journal of Mental Science·F Günther-GentaP Hohlfeld
May 1, 1993·Journal of Clinical Psychology·S N BrixeyL F Parmelee
Aug 1, 1993·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·B K LipskaD R Weinberger
Aug 1, 1993·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·L S PilowskyR M Murray
Mar 1, 1993·Archives of General Psychiatry·F E Bloom

❮ Previous
Next ❯

Citations

Mar 3, 2010·Progress in Neuro-psychopharmacology & Biological Psychiatry·Unn Kristin HaukvikIngrid Agartz
Oct 28, 2009·Progress in Neurobiology·Urs Meyer, Joram Feldon
Jul 16, 2008·Journal of Neuroscience Research·Helen AshdownPatricia Boksa
Aug 6, 2011·Biological Reviews of the Cambridge Philosophical Society·Matthew J HydePaul R Kemp
Jun 19, 2014·The International Journal of Eating Disorders·Angela FavaroPaolo Santonastaso
Apr 22, 2004·Pharmacology, Biochemistry, and Behavior·Karin Sandager-NielsenJørgen Scheel-Krüger
Dec 10, 2013·Lancet·Oliver D Howes, Robin M Murray
Oct 6, 2012·Early Human Development·Matthew James Hyde, Neena Modi
Mar 15, 2002·Neuroreport·Bassem F El-Khodor, Patricia Boksa
Nov 14, 2016·Developmental Cognitive Neuroscience·Marlen Z GonzalezJames A Coan
Apr 12, 2000·Pediatric Research·R MorleyT Dwyer
Jul 8, 2010·Neurotoxicity Research·Eva M MarcoGiovanni Laviola
Dec 20, 2005·Neuroreport·Yonina Levine, Patricia Boksa
Jul 31, 2001·Pediatric Research·G Ceresoli-Borroni, R Schwarcz
Jul 21, 2010·Clinical Schizophrenia & Related Psychoses·Christina Wilson, Alvin V Terry
Sep 15, 2012·Nihon yakurigaku zasshi. Folia pharmacologica Japonica·Kazuhito Ikeda
Nov 2, 2019·Developmental Psychobiology·María-José González-ValenzuelaErnesto González-Mesa
May 28, 2019·Frontiers in Psychology·María-José González-ValenzuelaDolores López-Montiel
Nov 23, 2017·Frontiers in Molecular Neuroscience·Alessandra PaparelliNori Takei
Jun 10, 2020·Canadian Journal of Physiology and Pharmacology·Elham Mohamadi-JorjafkiMaryam Raoof
Nov 5, 2020·Journal of Neuroendocrinology·William Kenkel
Mar 24, 2021·Cerebral Cortex·Morgane ChiesaYehezkel Ben-Ari
Mar 25, 2021·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Anna Rita ZuenaGemma Calamandrei

❮ Previous
Next ❯

Related Concepts

Related Feeds

Basal Ganglia

Basal Ganglia are a group of subcortical nuclei in the brain associated with control of voluntary motor movements, procedural and habit learning, emotion, and cognition. Here is the latest research.