Long-term recording performance and biocompatibility of chronically implanted cylindrically-shaped, polymer-based neural interfaces

Biomedizinische Technik. Biomedical Engineering
Richárd FiáthIstván Ulbert

Abstract

Stereo-electroencephalography depth electrodes, regularly implanted into drug-resistant patients with focal epilepsy to localize the epileptic focus, have a low channel count (6-12 macro- or microelectrodes), limited spatial resolution (0.5-1 cm) and large contact area of the recording sites (~mm2). Thus, they are not suited for high-density local field potential and multiunit recordings. In this paper, we evaluated the long-term electrophysiological recording performance and histocompatibility of a neural interface consisting of 32 microelectrodes providing a physical shape similar to clinical devices. The cylindrically-shaped depth probes made of polyimide (PI) were chronically implanted for 13 weeks into the brain of rats, while cortical or thalamic activity (local field potentials, single-unit and multi-unit activity) was recorded regularly to monitor the temporal change of several features of the electrophysiological performance. To examine the tissue reaction around the probe, neuron-selective and astroglia-selective immunostaining methods were applied. Stable single-unit and multi-unit activity were recorded for several weeks with the implanted depth probes and a weak or moderate tissue reaction was found around the prob...Continue Reading

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Citations

Aug 30, 2019·Advanced Healthcare Materials·Morgan FergusonFeng Zhao
Dec 4, 2019·Journal of Neural Engineering·Rik J J van DaalFabian Kloosterman
Jan 16, 2019·Scientific Reports·Richárd FiáthIstván Ulbert
May 16, 2020·Materials Science & Engineering. C, Materials for Biological Applications·Gergely MártonKinga Tóth

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