Long-term regression of experimental endometriosis in a rat model treated with local application of levonorgestrel-loaded biodegradable microspheres

Human Reproduction
Peng YuanXiaoyan Xin

Abstract

A previous study demonstrated that local application of levonorgestrel-loaded polylactic acid microspheres (LNG microspheres) resulted in significant regression of endometriotic cysts in a rabbit model for 6 months without disturbing the metabolic parameters or ovarian function. In order to investigate the feasibility of local application of LNG microspheres as a long-term maintenance treatment for endometriosis, the suppressive effect of a single intra-cystic injection of LNG microspheres was studied for 1 year in a rat model. Twenty four rats with experimental endometriotic cysts were randomized to be treated with a single intra-cystic injection of LNG microspheres (n = 8); 6-month GnRH agonist (GnRHa, n = 8) or control (n = 8). Intra-cystic injection of LNG microspheres and GnRHa treatment caused comparable regression and atrophy in endometriotic cysts in the first 6 months. Compared with the control, the wet weight of the endometriotic cysts was significantly lower in both groups at Month 6 but by Month 12 only remained low in the LNG microspheres group (P < 0.01). The immunostaining of estrogen receptors (ERs) in both the epithelium and stroma and progesterone receptors (PRs) in the stroma was significantly weakened in the...Continue Reading

References

Oct 1, 1979·American Journal of Obstetrics and Gynecology·L R BeckC E Flowers
Apr 1, 1994·European Journal of Obstetrics, Gynecology, and Reproductive Biology·J Ortega-Moreno
Apr 30, 2002·Obstetrics and Gynecology·Eric S Surrey, Mark D Hornstein
Oct 12, 2004·Fertility and Sterility·Erbil DoganBahadir Saatli
Nov 14, 2007·Epigenetics : Official Journal of the DNA Methylation Society·Steven G Gray, Fernando Dangond
Mar 13, 2009·Human Reproduction Update·Sun-Wei Guo
Aug 25, 2009·Medical Hypotheses·Peng YuanXiaoyan Xin

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Citations

Apr 29, 2015·PloS One·Mariela Andrea BilotasRosa Inés Barañao

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