Long-term-release GnRH agonists postpone puberty in domestic cats

Reproduction in Domestic Animals = Zuchthygiene
A RissoC Gobello

Abstract

The aim of this study was to assess the efficacy and safety of deslorelin acetate implants on domestic queen puberty postponement. Thirty, 114.4 ± 12.7 days old, 1.5 ± 0.1 kg prepubertal crossbred female cats were included in this study. The animals were kept under a positive photoperiod and randomly assigned to deslorelin acetate 4.7 mg SC implants (n = 15) or to a non-treated control group (n = 15). The queens were followed up daily and weighed weekly until puberty. Vaginal cytology was also carried out three times a week. Puberty was diagnosed by the presence of the typical oestrous behaviour and vaginal cytology findings. At puberty, ovariectomy was performed and the gonads grossly described. Age (281.2 ± 21.6 vs 177.8 ± 10.8; p < 0.01) but not weight (2.6 ± 0.1 vs 2.5 ± 0.1; p > 0.1) at puberty differed between the deslorelin and control groups, respectively. One deslorelin-treated female showed an oestrous response and another showed clinical signs of pyometra after the implants. Deslorelin-treated ovaries appeared small, while control gonads were normal. It was concluded that long-term-release deslorelin, administered at approximately 50% adult body weight, postponed feline puberty without altering growing rate.

Citations

Jan 4, 2013·Reproduction in Domestic Animals = Zuchthygiene·C MaenhoudtA Fontbonne
Jan 29, 2014·Reproduction in Domestic Animals = Zuchthygiene·G MarinoA Zanghì
Jun 21, 2014·Reproduction in Domestic Animals = Zuchthygiene·S Schäfer-SomiS Aslan
Jun 21, 2014·Reproduction in Domestic Animals = Zuchthygiene·S Goericke-PeschP Georgiev
Apr 15, 2014·Theriogenology·A CarranzaC Gobello
Dec 28, 2016·Reproduction in Domestic Animals = Zuchthygiene·S Goericke-Pesch
Feb 15, 2017·Journal of Feline Medicine and Surgery·Marta CecchettoStefano Romagnoli
Sep 2, 2015·Journal of Feline Medicine and Surgery·Christelle Fontaine
Feb 23, 2020·Journal of Feline Medicine and Surgery·Etienne FurthnerAlain Fontbonne
Mar 25, 2020·Anatomical Science International·Wanpitak PongkanKorakot Nganvongpanit
Oct 4, 2014·Reproduction in Domestic Animals = Zuchthygiene·X Lucas
Dec 5, 2020·Tierärztliche Praxis. Ausgabe K, Kleintiere/Heimtiere·Sabrina Stempel, Sandra Goericke-Pesch
Jul 22, 2018·General and Comparative Endocrinology·Morgan A MalyAdrienne E Crosier
Oct 6, 2021·Reproduction in Domestic Animals = Zuchthygiene·L Ferré-DolcetS Romagnoli
Dec 1, 2021·Reproduction, Fertility, and Development·Morgan A MalyAdrienne E Crosier

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