Long-term remission in advanced stage hepatocellular carcinoma? A chance for cure?

Memo
Matthias Pinter, Wolfgang Sieghart

Abstract

Liver resection, transplantation, and local ablation are potential curative treatment options but can only be offered to patients with early stage hepatocellular carcinoma (HCC). Patients with macrovascular tumor invasion and extrahepatic metastases are candidates for palliative systemic therapies. Achieving radiological complete response can be associated with long-term remission and excellent outcome. However, despite recent advancements in the medical treatment of advanced stage HCC, complete remission with available systemic treatment options still remains a rare event. This review summarizes data on radiological complete response to systemic therapies and discusses issues that may complicate the goal of achieving cure in advanced stage HCC.

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Citations

May 26, 2021·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Alice BoilèveValérie Boige

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Clinical Trials Mentioned

NCT02576509
NCT02702401
NCT03062358
NCT03298451
NCT03434379

Software Mentioned

mRECIST
iRECIST
SHARP

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