PMID: 11917050Mar 28, 2002Paper

Long-term renal injury in ANCA-associated vasculitis: an analysis of 31 patients with follow-up biopsies

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
Herbert A HauerJ A Bruijn

Abstract

We reported previously that in renal disease in relation to antineutrophil cytoplasm auto-antibodies (ANCA)-associated vasculitis, renal outcome correlates better with the percentage of normal glomeruli than with separate active lesions. This may imply that glomeruli, once affected by necrotizing and crescentic lesions, are irreversibly damaged. We quantified and evaluated the course of renal lesions in the present study. We retrospectively analysed 31 patients with renal disease in relation to ANCA-associated vasculitis, all treated with immunosuppressive drugs. In all patients, a renal biopsy was performed at diagnosis. A follow-up biopsy was performed in all patients on the indication of a suspected renal relapse, after a mean interval of 31 months. The mean percentage of normal glomeruli in the renal biopsy did not change over time (29% in the initial and 30% in the follow-up biopsy). The mean percentage of glomeruli with crescents, however, significantly decreased from 57 to 30% (P<0.001). The percentage of glomerulosclerosis significantly increased from 12 to 39% (P<0.001). The data were independent of diagnosis, gender, age, time interval between the biopsies, and treatment. This is the first study to quantify glomerular...Continue Reading

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Citations

Nov 18, 2004·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Irmgard NeumannFranz Thomas Meisl
Jan 28, 2005·Kidney International·Wilhelm Kriz, Michel LeHir
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Jan 30, 2014·Journal of Nephropathology·Kresimir GalesicIvica Horvatic
Mar 1, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Zdenka HruskovaVladimir Tesar
Apr 22, 2014·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Luis F QuintanaDavid Jayne
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Mar 26, 2015·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Emma van DaalenIngeborg M Bajema
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Nov 13, 2019·Néphrologie & thérapeutique·Aghilès HamrounFrançois Glowacki
Apr 30, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nadja SpardingVladimir Tesar
Apr 25, 2006·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Renato Alberto SinicoCarlo Buzio
Aug 27, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Marta Casal MouraSanjeev Sethi

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