Long-term renal outcome in pediatric glomerulonephritis associated with crescent formation

Clinical and Experimental Nephrology
Pornpimol Rianthavorn, Manunya Chacranon

Abstract

Information on long-term renal outcome of pediatric glomerulonephritis associated with crescent formation is limited. A single center retrospective study was conducted to assess long-term renal survival and to determine whether the 2010 classification for antineutrophil cytoplasmic antibody (ANCA)-associated glomerulonephritis can predict renal outcome in pediatric glomerulonephritis associated with crescent formation. Biopsy and clinical data of children, aged ≤ 18 years with ≥ 10 glomeruli and ≥ 10% crescentic glomeruli during January 1998 to December 2015, were reviewed. Biopsies were classified according to the 2010 classification into focal, crescentic, mixed, and sclerotic classes. The clinical endpoint was end-stage renal disease (ESRD). Of 72 children, 14 patients (19.4%) had positive ANCA. The biopsy indication was rapidly progressive glomerulonephritis in 38 patients (52.8%) and 22 patients (30.6%) required dialysis at onset. Lupus nephritis was the most common diagnosis (43.1%), followed by IgA nephropathy/Henoch-Schoenlein purpura (HSP) (22.2%). ESRD occurred in 18 patients (25%) and the risk of ESRD differed among the histological classifications (p < 0.001). Dialysis at onset and sclerotic class was independent pr...Continue Reading

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Citations

Jul 12, 2019·Clinical and Experimental Medicine·Zheng-Xia ZhongWei Qin
Oct 13, 2019·Clinical and Experimental Nephrology·Jingjing ChenShao Liu
Nov 22, 2020·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Licia Peruzzi, Rosanna Coppo
Apr 28, 2021·International Urology and Nephrology·Xinyao LuoYahong Hu
Apr 17, 2020·Kidney & Blood Pressure Research·Precil Diego Miranda de Menezes NevesViktoria Woronik

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