Long-term renal outcomes associated with sodium glucose cotransporter 2 inhibitors in patients with type 2 diabetes mellitus: A systematic review and meta-analysis.

Diabetes/metabolism Research and Reviews
Xiaodan ZhangWangen Li

Abstract

The long-term impact of sodium glucose cotransporter 2 (SGLT2) inhibitors on renal functions remains undefined. This study was undertaken to investigate the renal outcomes associated with SGLT2 inhibitors in patients with type 2 diabetes (T2DM) in the long term. A systematic literature search of PubMed and ClinicalTrials.gov was conducted. Randomized controlled trials which reported renal outcomes at the study endpoint in patients with T2DM receiving treatments of SGLT2 inhibitors were included. Renal adverse events were determined using prespecified lists from the Medical Dictionary for Regulatory Activities or laboratory values. Odds ratio with 95% confidence interval (CI) was used for assessment of dichotomous data. The mean difference or standardized mean difference with 95% CI was used for assessment of continuous data. Random effects models were adopted to measure the pooled outcomes. Thirty-nine studies involving 35 trials were identified. Compared with placebo or other anti-diabetic medications, SGLT2 inhibitors were associated with significant lower incidence of composite renal outcome and acute renal failure or injury in patients with T2DM. The risk of progression of albuminuria also appeared to be decreased. No signi...Continue Reading

References

Sep 6, 2003·BMJ : British Medical Journal·Julian P T HigginsDouglas G Altman
Jul 23, 2009·BMJ : British Medical Journal·David MoherUNKNOWN PRISMA Group
Aug 6, 2013·Diabetes, Obesity & Metabolism·J P H WildingUNKNOWN Dapagliflozin 006 Study Group
Nov 11, 2014·Diabetic Medicine : a Journal of the British Diabetic Association·C J BaileyJ F List
Apr 22, 2015·Current Hypertension Reports·J A Lovshin, R E Gilbert
Jun 3, 2015·Diabetic Medicine : a Journal of the British Diabetic Association·L MerkerUNKNOWN EMPA-REG EXTEND MET investigators
Jul 3, 2015·Therapeutic Advances in Endocrinology and Metabolism·Deborah Hinnen
Jul 4, 2015·Clinical Therapeutics·Christopher S KovacsUNKNOWN EMPA-REG EXTEND™ PIO investigators
Sep 2, 2015·Diabetes Research and Clinical Practice·Hans-Ulrich HaeringUNKNOWN EMPA-REG EXTEND™ METSU investigators
Feb 20, 2016·Journal of Nephrology·Donald Elliott KohanLisa Ying
Jun 9, 2016·Endocrine·R P Monica Reddy, Silvio E Inzucchi
Jun 15, 2016·The New England Journal of Medicine·Christoph WannerUNKNOWN EMPA-REG OUTCOME Investigators
Jul 22, 2016·Diabetes Care·Paola FiorettoRoberto Vettor
Aug 20, 2016·Journal of the American Society of Nephrology : JASN·Hiddo J L HeerspinkVlado Perkovic
Dec 13, 2016·Nature Reviews. Nephrology·Ralph A DeFronzoMuhammad Abdul-Ghani
Jan 19, 2017·Diabetes/metabolism Research and Reviews·Hongyu QiuVolker Vallon
Apr 12, 2017·International Journal of Cardiology·Pasquale Perrone-FilardiEle Ferrannini
May 21, 2017·The American Journal of Medicine·Christoph Wanner

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Citations

Feb 9, 2021·Therapeutic Advances in Drug Safety·Ryan PelletierJohn-Michael Gamble
Dec 31, 2020·Clinical Journal of the American Society of Nephrology : CJASN·Min ZhaoHuilin Tang

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