Long-term repeatability of measures of early insulin secretion derived from an intravenous glucose tolerance test and conversion from impaired glucose tolerance to diabetes

Annals of Medicine
David E LaaksonenMatti Uusitupa

Abstract

We assessed the long-term repeatability of the acute insulin response (AIR) and sensitivity index (S(I)) derived from the frequently sampled intravenous glucose tolerance test (FSIGT). An FSIGT was performed in 20 women who participated in a 6.5-month rye- and wheat-bread intervention trial, 70 men and women with impaired fasting glycaemia (IFG) or impaired glucose tolerance (IGT) who participated in the Genobin study, and 81 men and women with IGT who participated in the Finnish Diabetes Prevention Study (DPS). The correlation of AIR and S(I) at base-line with respective values after the 6.5-8.5-month trials was 0.86-0.88 and 0.71-0.84, and before and after 4 years in the DPS substudy, 0.86 and 0.53. In multivariate analyses, AIR (relative risk for a 1-SD change, 0.67; 95% confidence intervals 0.46-0.97) predicted the conversion from IGT to diabetes in the DPS substudy. AIR is highly repeatable even after 4 years of follow-up. The long-term repeatability of S(I) is moderate. Our findings emphasize the importance of impaired early insulin secretion in the transition from IGT to diabetes, and the high degree of tracking of measures of early insulin secretion derived from the FSIGT.

References

Jan 1, 1991·Journal of Clinical Epidemiology·E J FeskensD Kromhout
Jul 21, 2000·The Journal of Clinical Endocrinology and Metabolism·A KatzM J Quon
May 3, 2001·The New England Journal of Medicine·J TuomilehtoUNKNOWN Finnish Diabetes Prevention Study Group
Jan 5, 2002·Diabetes Care·Mayer B Davidson
Jan 30, 2002·Diabetes·Richard N BergmanGregg Van Citters
Jan 24, 2003·The American Journal of Clinical Nutrition·Katri S JuntunenHannu M Mykkänen
Jun 8, 2004·The Journal of Clinical Endocrinology and Metabolism·Kristina M UtzschneiderRobert S Schwartz
Jul 15, 2004·American Journal of Physiology. Endocrinology and Metabolism·Flemming DelaHenrik Galbo
Jul 24, 2004·American Journal of Physiology. Endocrinology and Metabolism·Jens Juul Holst, Jesper Gromada
Oct 14, 2004·Annals of Medicine·David E LaaksonenMatti Uusitupa
Dec 8, 2005·The American Journal of Clinical Nutrition·David E LaaksonenHannu M Mykkänen

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