Long-Term Residual-Mobility and Adjacent Segment Disease After Total Lumbar Disc Replacement.

Global Spine Journal
Joep KitzenPaul C P H Willems

Abstract

Retrospective cohort study. Total disc replacement (TDR) has been introduced in order to preserve segmental motion and thus reduce adjacent segment disease (ASD) as seen after spinal fusion. However, it is uncertain whether these presumed beneficial effects remain. The aim of this study was to evaluate the long-term incidence of ASD and residual-mobility in relation to clinical outcome. A total of 210 patients treated with lumbar TDR for degenerative disc disease were invited for follow-up. ASD was reported in case of severe degeneration in an adjacent disc at latest follow-up, or if an increase in disc degeneration was observed in these adjacent segments as compared to direct postoperative radiographs. Residual-mobility of the TDR was defined as a minimal rotation of 4.6° on flexion-extension radiographs. Patient-reported outcome measures were obtained. Fifty-seven patients (27.1%) were lost to follow-up. In 32 patients (15.3%) a revision by spinal fusion had been performed. In 20 patients this revision had occurred ≥5 years after TDR and were included. Consequently, 141 patients were available for analysis (mean follow-up of 16.7 years). Residual-mobility was noted in 38.0%. No significant associations were observed between r...Continue Reading

References

Oct 18, 2002·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Helmut D Link
Jun 17, 2005·Spine·Richard A DeyoBrook I Martin
Jul 16, 2005·Journal of Spinal Disorders & Techniques·Jean-Philippe LemaireFrançois Lavaste
Oct 29, 2005·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Michael PutzierFrank Kandziora
Dec 6, 2005·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Hans-Joachim WilkeAnnette Kettler
May 2, 2006·Spine·Moe R LimFrank P Cammisa
Apr 2, 2010·The Journal of Bone and Joint Surgery. British Volume·K KafchitsasM Rauschmann
Dec 21, 2010·The Spine Journal : Official Journal of the North American Spine Society·William R SearsBarbara Osburg
Feb 7, 2013·The Spine Journal : Official Journal of the North American Spine Society·Adam R MeirShaun M Fowler
Jun 19, 2013·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Ilona PuntPaul Willems
Apr 22, 2015·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Shi-bao LuYu Wang
Jul 5, 2017·The Spine Journal : Official Journal of the North American Spine Society·Christoph WuertingerChristoph J Siepe

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