Long-term results in patients with onychomycosis treated with terbinafine or itraconazole

The British Journal of Dermatology
H Heikkilä, S Stubb

Abstract

Previously, a double-blind, randomized, multicentre study (LION study) compared the efficacy of continuous terbinafine 250 mg daily for 3 or 4 months with itraconazole pulse therapy 400 mg daily for 3 or 4 months. At the end of the study at week 72 terbinafine proved to be more effective. To perform a 4-year follow-up of the Finnish participants in this study. Patients were re-examined clinically and mycologically. Complete clinical and mycological cure with terbinafine for 4 months was 78% compared with 35% with terbinafine for 3 months, 24% with itraconazole for 4 months and 28% with itraconazole for 3 months. These results suggest that the initial treatment for onychomycosis should be a 4-month continuous course of terbinafine.

References

May 1, 1992·Journal of the American Academy of Dermatology·M WillemsenD Roseeuw
Nov 1, 1995·The British Journal of Dermatology·H Heikkilä, S Stubb

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Citations

May 15, 2009·The New England Journal of Medicine·David de Berker
May 6, 2004·Medical Mycology·C S OsborneN S Ryder
Jan 1, 2009·Clinical, Cosmetic and Investigational Dermatology·Jason G Newland, Susan M Abdel-Rahman
Aug 11, 2004·American Journal of Clinical Dermatology·Aditya K GuptaMaria M Chaudhry
Jul 27, 2011·Medical Mycology Journal·Takashi Harada
Dec 20, 2013·American Journal of Clinical Dermatology·Daniel Coelho de SáAntonella Tosti
Feb 10, 2006·The Journal of Dermatological Treatment·Bardur SigurgeirssonRajesh Bakshi
Jun 7, 2005·Expert Opinion on Pharmacotherapy·Robert BaranGerald E Piérard
Nov 12, 2009·Journal of Pharmaceutical Sciences·Kelly A SmithS Kevin Li
Jun 27, 2006·Dermatologic Clinics·Aditya K Gupta, Linh Q Tu
Nov 12, 2005·Skinmed·Aditya K GuptaElizabeth A Cooper
Mar 20, 2004·The British Journal of Dermatology·A K GuptaA M Johnson
May 15, 2009·Journal of the European Academy of Dermatology and Venereology : JEADV·A K GuptaE A Cooper
Aug 24, 2007·Journal of the European Academy of Dermatology and Venereology : JEADV·M-H Schmid-Wendtner, H C Korting
Apr 4, 2007·Dermatologic Therapy·Justin J Finch, Erin M Warshaw
Sep 14, 2010·Journal of Clinical Pharmacy and Therapeutics·J ThomasC Sharpe
Sep 29, 2004·Clinics in Podiatric Medicine and Surgery·Frances J Lagana
Sep 29, 2004·Clinics in Podiatric Medicine and Surgery·Warren S Joseph
Mar 17, 2004·Dermatologic Clinics·Daniel S Loo
Sep 6, 2003·Dermatologic Clinics·Aditya K Gupta, Jennifer E Ryder
Aug 19, 2005·Expert Review of Anti-infective Therapy·Adolfo C Fernandez-ObregonCarolyn Willis
Jul 15, 2017·The Cochrane Database of Systematic Reviews·Sanne Kreijkamp-KaspersMieke L van Driel
Jan 18, 2006·Journal of the American Podiatric Medical Association·Erin M Warshaw
Dec 13, 2002·American Journal of Clinical Dermatology·Malcolm J M DarkesKaren L Goa

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