PMID: 11900939Mar 20, 2002Paper

Long-term results of a clinical trial on dermal substitution. A light microscopy and Fourier analysis based evaluation

Burns : Journal of the International Society for Burn Injuries
Paul P M van ZuijlenEsther Middelkoop

Abstract

Although dermal substitution is a main topic of current wound healing research, there is a paucity of clinical trials with a long-term clinical and histopathological evaluation. A clinical trial was conducted to perform an intra-individual comparison of conventional treatment (split-thickness autograft) to a collagen/elastin dermal substitute in combination with an autograft. Promising results with this substitute were obtained with respect to dermal organisation and scar elasticity in animal studies and clinical trials with a short-term follow-up. Twenty-nine of the 42 pairs of the burn wounds and 28 of the 44 pairs of the scar reconstructions enrolled in the study were biopsied after 1 year. Promising but not statistically significant differences were found between substituted groups and control groups for epidermal thickness, basement membrane maturation, rete ridges (P=0.055), fibroblasts, myofibroblasts, inflammatory cells, vessels and extracellular matrix maturation. An objective and accurate technique, Fourier analysis, was used to evaluate collagen bundle orientation and packing. However, no statistically significant differences were obtained for these parameters. This microscopic evaluation provided no convincing evide...Continue Reading

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Citations

Mar 2, 2011·Applied Microbiology and Biotechnology·Andreia Vasconcelos, Artur Cavaco-Paulo
Feb 22, 2003·Journal of the American College of Surgeons·Jeffrey R Saffle
Nov 6, 2010·Tissue Engineering. Part B, Reviews·Gerwen LammersWilleke F Daamen
May 5, 2010·Plastic and Reconstructive Surgery·Monica C T BloemenEsther Middelkoop
Aug 27, 2013·BMC Bioinformatics·Osman S OsmanKenneth Langlands
Apr 9, 2013·Nanomedicine·Rúben F PereiraPaulo J Bartolo
May 8, 2010·Chemical Society Reviews·Jessica F AlmineAnthony S Weiss
Nov 17, 2006·The Journal of Investigative Dermatology·Jeffrey M Davidson, Mariagabriella Giro
Nov 17, 2007·Journal of Anatomy·Heiko SorgBrigitte Vollmar
Aug 14, 2013·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Jeroen W J van KilsdonkJoost Schalkwijk
Sep 22, 2009·Journal of Biophotonics·Xiaoqin ZhuBifang Lin
Dec 4, 2014·Advanced Healthcare Materials·Yiwei WangAnthony S Weiss
Nov 2, 2014·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Maria WiednerDavid B Lumenta
Jul 20, 2005·Journal of Biomedical Materials Research. Part a·Hongjun WangEvert N Lamme
Sep 17, 2013·Burns : Journal of the International Society for Burn Injuries·M Jenda HopUNKNOWN TOPSKIN Study Group
Sep 23, 2011·Aesthetic Surgery Journal·David J Wainwright, Sean B Bury
Jan 8, 2005·The International Journal of Artificial Organs·P J FahnerT M van Gulik
Oct 29, 2021·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·Douglas W HamiltonLauren E Flynn

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