Jan 25, 2008

Long-term results of ABO-incompatible kidney transplantation with antigen-specific immunoadsorption and rituximab

Transplantation
Helena GenbergGunnar Tydén

Abstract

ABO-incompatible (ABOi) kidney transplantation has gained a renewed interest during the past years. In 2001, a protocol for ABOi kidney transplantation based on antigen-specific immunoadsorption and rituximab was introduced at our center. In this study long-term graft function using this protocol was assessed. All ABOi kidney recipients with >1-year follow-up (n=15) were compared with all ABO-compatible (ABOc) living donor kidney recipients maintained on the same basic immunosuppression (n=27). Patient and graft survival as well as rejections and calculated glomerular filtration rate were analyzed. Mean follow-up was 3 years. There was no significant difference in patient and graft survival nor in rejection episodes. Mean glomerular filtration rate (79-83 ml/min) was equivalent at 1, 2, and 3 years in both groups. We conclude that ABOi kidney transplantation using antigen-specific immunoadsorption and rituximab is equivalent to standard ABOc living donor kidney transplantation. ABOi transplantation following this protocol does not have a negative impact on graft function long-term.

  • References10
  • Citations32

References

  • References10
  • Citations32

Citations

Mentioned in this Paper

Monoclonal Antibodies
Decreased Immunologic Activity [PE]
Blood Group H Type 1 Antigen
Graft Survival
Kidney
Adsorption
Glomerular Filtration Rate
Antigens
Immunosorbents
Transfusion Reaction

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