PMID: 8595781Mar 1, 1996Paper

Long-term results of allograft replacement in the management of bone tumors

Clinical Orthopaedics and Related Research
H J MankinW W Tomford

Abstract

Over the past 24 years, the authors have implanted >870 massive frozen cadaveric allografts mostly for the treatment of defects created by the resection of a bone tumor. Most of the grafts were obtained from the authors' institutional bone bank. The results show that only stage and type of graft affected outcome predictably. Specifically, grafts for a Stage 2 or Stage 3 tumor had a poorer outcome than those for Stages 0 and 1. The results for allograft arthrodeses were considerably poorer than osteoarticular, intercalary, and allograft plus prosthesis. The other major factors in results were complications--recurrence, infection, fracture, and nonunion--with the former 2 having a profound negative effect on outcome. After the first year of susceptibility to infection (10%) and the third year of increased risk of fracture (19%), the grafts become stable, and approximately 75% are retained by patients and are considered to be successful for >20 years after implantation. Osteoarthritis becomes a problem at approximately 6 years for osteoarticular grafts, and so far, 16% of the patients with distal femoral, proximal tibial, or proximal femoral grafts have required total joint replacements. Although the current results are adequate, ...Continue Reading

References

Feb 1, 1988·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·K WinklerV Gerein
Jun 19, 1986·The New England Journal of Medicine·M P LinkJ A Kirkpatrick
Jan 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·F EilberJ Goodnight
Mar 1, 1987·The Journal of Bone and Joint Surgery. British Volume·C F BradishJ N Wilson
Jan 1, 1985·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·V M GoldbergK G Heiple
Dec 26, 1985·The New England Journal of Medicine·A M GoorinE Frei

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Citations

Jan 8, 1998·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·K U LewandrowskiH J Mankin
Jan 8, 1998·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·D R YoungE Y Chao
Apr 13, 1999·The Journal of Bone and Joint Surgery. American Volume·F Y LeeL C Jennings
May 8, 2002·Plastic and Reconstructive Surgery·Lior HellerL Scott Levin
Apr 16, 2002·Clinical Orthopaedics and Related Research·Yasser RefaatHenry J Mankin
Jun 20, 2002·Clinical Orthopaedics and Related Research·D DonatiMark C Gebhardt
Dec 11, 2002·Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society·Dennis M CullinaneEdmund Y S Chao
Aug 20, 2003·Journal of Biomedical Materials Research. Part a·Toshihiro MatsuoTeruo Murakami
Feb 6, 2004·Journal of Surgical Oncology·Craig H GerrandJay S Wunder
Sep 15, 2004·Veterinary Surgery : VS·Julius M LiptakStephen J Withrow
Jun 3, 2005·Clinical Orthopaedics and Related Research·Matthew R DiCaprioMark T Scarborough
Jun 3, 2005·Clinical Orthopaedics and Related Research·Donna L Wheeler, William F Enneking
Feb 1, 2006·Expert Review of Anticancer Therapy·Hazem Wafa, Robert J Grimer
May 17, 2006·Clinical Orthopaedics and Related Research·Naftaly Attias, Ronald W Lindsey
Nov 9, 2006·Clinical Orthopaedics and Related Research·David Jean BiauPhilippe Anract
Nov 1, 2006·The Journal of Bone and Joint Surgery. British Volume·K A MichalakD J Wood
Mar 14, 2007·Clinical Orthopaedics and Related Research·Luke H BalsamoH Thomas Temple
Feb 20, 2008·Archives of Orthopaedic and Trauma Surgery·Sercan AkpinarReha N Tandogan
May 29, 2008·Clinical Orthopaedics and Related Research·Hubert T KimAlexis C Dang
Feb 29, 2008·Yonsei Medical Journal·Yoon Hae KwakHyun Woo Kim
Jan 7, 2009·Journal of Cancer Research and Clinical Oncology·Shui-er ZhengLi-na Tang
Oct 7, 2008·Clinical Orthopaedics and Related Research·John H HealeyPatrick J Boland
May 22, 2009·BMC Musculoskeletal Disorders·Eline W ZwitserBarend J van Royen
Apr 27, 2010·Clinical Orthopaedics and Related Research·Raffi S AvedianTerrance D Peabody
Nov 16, 2010·Cell and Tissue Banking·Eline W ZwitserBarend J van Royen
Feb 4, 2011·Clinical Orthopaedics and Related Research·Olav ReikeråsBent Rolstad
Jul 20, 2011·The Journal of Bone and Joint Surgery. British Volume·M D SewellT W R Briggs
Dec 17, 2011·Journal of Pediatric Orthopedics·Richard H Gross
Jul 4, 2012·Operative Orthopädie und Traumatologie·A StreitbürgerG Gosheger
Dec 21, 2012·Journal of Orthopaedic Surgery·Aziz NatherBarry P Pereira
Jan 10, 2013·Annals of Biomedical Engineering·Habib BousleimanMauricio Reyes
Nov 20, 2012·Asia-Pacific Journal of Clinical Oncology·Olarn ArpornchayanonPhonthakorn Panichkul
Oct 16, 2013·Annals of Plastic Surgery·Samir Z Kotb, Mohamed F Mostafa
May 6, 2014·Clinical Orthopaedics and Related Research·Luis A Aponte-TinaoGermán L Farfalli

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