Long-term results of an RTOG Phase II trial (00-19) of external-beam radiation therapy combined with permanent source brachytherapy for intermediate-risk clinically localized adenocarcinoma of the prostate

International Journal of Radiation Oncology, Biology, Physics
Colleen A LawtonHoward M Sandler

Abstract

External-beam radiation therapy combined with low-doserate permanent brachytherapy are commonly used to treat men with localized prostate cancer. This Phase II trial was performed to document late gastrointestinal or genitourinary toxicity as well as biochemical control for this treatment in a multi-institutional cooperative group setting. This report defines the long-term results of this trial. All eligible patients received external-beam radiation (45 Gy in 25 fractions) followed 2-6 weeks later by a permanent iodine 125 implant of 108 Gy. Late toxicity was defined by the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer late radiation morbidity scoring scheme. Biochemical control was defined by the American Society for Therapeutic Radiology and Oncology (ASTRO) Consensus definition and the ASTRO Phoenix definition. One hundred thirty-eight patients were enrolled from 20 institutions, and 131 were eligible. Median follow-up (living patients) was 8.2 years (range, 2.7-9.3 years). The 8-year estimate of late grade >3 genitourinary and/or gastrointestinal toxicity was 15%. The most common grade >3 toxicities were urinary frequency, dysuria, and proctitis. There were two grade 4 toxicitie...Continue Reading

References

Oct 25, 2003·International Journal of Radiation Oncology, Biology, Physics·Deborah A KubanAnthony L Zietman
Jan 5, 2005·International Journal of Radiation Oncology, Biology, Physics·Gregory S MerrickEdward Adamovich
May 27, 2009·International Journal of Radiation Oncology, Biology, Physics·Al V TairaWayne M Butler

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Citations

Dec 17, 2014·Seminars in Oncology·J Nicholas LukensLouis B Harrison
Apr 14, 2016·Journal of Cancer Research and Therapeutics·Arti ParekhMark D Hurwitz
Jun 4, 2013·Clinical Oncology : a Journal of the Royal College of Radiologists·G C Morton, P J Hoskin
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May 15, 2016·Brachytherapy·Borut Kragelj, Lijana Zaletel-Kragelj
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Sep 25, 2019·International Journal of Urology : Official Journal of the Japanese Urological Association·Nobumichi TanakaKiyohide Fujimoto
Jun 6, 2020·International Journal of Clinical Oncology·Tomoki TaniguchiTakuya Koie
Jun 5, 2020·Reports of Practical Oncology and Radiotherapy : Journal of Greatpoland Cancer Center in Poznań and Polish Society of Radiation Oncology·O Pons-LlanasJ López-Torrecilla

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